Isothiocyanate Dental Composition for Dentin Calcification
Solution Overview
Problem
Current dental care compositions fail to effectively promote calcification in living body tissues, particularly in teeth and periodontal tissues, due to limitations in activating TRPA1 channels and carbonic anhydrase, which are crucial for dentin formation and repair.
Innovation Solution
A dental care composition containing isothiocyanates with specific functional groups such as sulfinyl, sulphonyl, sulfide bonds, or aryl groups, including methylsulfinylalkyl isothiocyanate and 6-methylsulfinylhexyl isothiocyanate, which activate TRPA1 channels and carbonic anhydrase, promoting calcification by increasing intracellular calcium and creating an alkaline environment for calcium deposition.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional dental care compositions are used, then basic dental hygiene is maintained, but calcification promotion in living body tissue is insufficient
Solution Approach 1:
The patent changes the chemical parameters of the composition by incorporating isothiocyanates with specific functional groups (sulfinyl, sulphonyl, sulfide bonds, or aryl groups). These chemical parameter changes enable activation of TRPA1 channels and carbonic anhydrase, thereby significantly improving calcification promotion effect and dentin formation rate compared to conventional compositions.
Solution Approach 2:
The patent creates a composite dental care composition by combining isothiocyanates with specific functional groups along with other dental care ingredients. This composite approach synergistically enhances the calcification promotion effect and accelerates dentin formation while maintaining basic dental hygiene benefits.
2Reliability
If TRPA1 channels and carbonic anhydrase are activated, then calcification is promoted, but the complexity of the composition increases
Solution Approach 1:
The isothiocyanates with specific functional groups serve multiple functions: they activate TRPA1 channels, stimulate carbonic anhydrase, and promote calcification. This multi-functionality allows a single ingredient class to achieve multiple therapeutic effects, reducing the need for multiple separate agents and thereby limiting the increase in composition complexity.
Solution Approach 2:
By optimizing the chemical structure parameters of isothiocyanates (selecting specific functional groups and carbon chain lengths), the patent achieves effective activation of TRPA1 channels and carbonic anhydrase while maintaining composition simplicity. The parameter optimization ensures high efficacy without requiring complex formulation.
3Productivity
If isothiocyanates with specific functional groups are used, then dentin formation is accelerated, but the risk of hyperesthesia may increase
Solution Approach 1:
The patent applies local quality by directing the calcification promotion effect specifically to the dentin tissue through localized delivery mechanisms (such as toothpaste application or chewing gum placement). This localized approach ensures that the isothiocyanates act on the target tissue (dentin) without causing systemic effects or hyperesthesia in other areas.
Solution Approach 2:
The patent uses partial action by employing controlled, low-to-moderate concentrations of isothiocyanates that are sufficient to activate TRPA1 channels and promote dentin formation, but not so high as to cause harmful effects like hyperesthesia. The dosage is optimized to achieve the minimum effective concentration for calcification promotion while avoiding excessive action.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively promotes calcification of dentin, enhancing dental tissue strength, preventing hyperesthesia, and accelerating dentin formation and repair, with demonstrated efficacy in both in vitro and in vivo studies.
Implementation Method 1
it has been proven that various membrane channel responsive to external stimuli expressed in the odontoblasts are involved in calcification of the dentin. For example, Non-Patent Document 1 discloses that calcification of the dentin is inhibited by an addition of an inhibitor of TRPA1 (TRP: transient receptor potential) channel expressed in the odontoblasts
Implementation Method 2
the composition effectively promotes calcification of dentin, enhancing dental tissue strength, preventing hyperesthesia, and accelerating dentin formation and repair
Implementation Method 3
promoting calcification by increasing intracellular calcium and creating an alkaline environment for calcium deposition
Data Source
AI summary
A dental care composition including an isothiocyanate having a sulfinyl group (—S(═O)—), a sulphonyl group (—S(═O)2—), a sulfide bond (—S—), or an aryl group, and an isothiocyanate group (—N═C═S). And, a composition used to promote activation of a TRPA1 channel and to promote activation of a reaction catalyzed by carbonic anhydrase.