Isoxazoline Pesticide Compounds with Extended Half-Life
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Solution Overview
Problem
Current veterinary and agricultural treatments for ectoparasites in companion animals and livestock often require frequent administration and have limited duration of action, which can be inconvenient and costly.
Innovation Solution
Development of a compound of formula (I) with extended half-life that provides long-lasting protection against ectoparasites in warm-blooded animals, such as dogs, cats, and cattle, after a single oral administration or injection, effectively treating and controlling ectoparasites for months.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of moving object
If current veterinary and agricultural treatments for ectoparasites are used, then ectoparasite control is achieved, but frequent administration is required and duration of action is limited
Solution Approach 1:
The patent modifies the chemical structure of isoxazoline compounds by changing parameters such as introducing fluorine atoms at specific positions (R2 and/or R4), modifying the heteroaryl group (X), and adjusting substituents (R5-R10, W1-W6). These structural parameter changes result in compounds with extended half-life and prolonged duration of action against ectoparasites, allowing for less frequent administration while maintaining effective control.
2Reliability
If frequent administration of ectoparasite treatments is performed, then ectoparasite control is maintained, but convenience and cost increase
Solution Approach 1:
By modifying the chemical parameters of the isoxazoline compounds (introducing fluorine atoms, modifying heteroaryl groups, adjusting substituents), the patent creates compounds that maintain reliable ectoparasite control over extended periods. This prolonged duration of action reduces the frequency of administration, thereby improving convenience for animal owners while maintaining effective pest control reliability.
3Reliability
If current ectoparasite treatments are used, then pest control is achieved, but treatment cost increases due to frequent administration
Solution Approach 1:
The patent modifies the chemical structure of isoxazoline compounds by introducing fluorine atoms at specific positions and adjusting heteroaryl groups and substituents. These parameter changes result in compounds with extended half-life that provide prolonged pest control duration. Consequently, fewer treatments are required over time, reducing the total quantity of substance administered and lowering overall treatment costs while maintaining reliable pest control effectiveness.
Data Source
AI summary
The present invention provides compounds of formula (I):which are useful for long-lasting treatment and control of pests, optionally fleas and ticks, in companion animals and livestock, and pharmaceutical compositions and methods of using the same.