Isoxazoline Compounds for Parasite Control
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Solution Overview
Problem
Current pesticidal and parasiticidal compounds are ineffective against certain ectoparasites and endoparasites that infest animals, and there is a need for compounds that can also control invertebrate pests damaging crops and plants, as resistance to existing agents is a significant issue.
Innovation Solution
Development of novel isoxazoline compounds of formula (I) that are biologically active against parasites harming animals and pests damaging crops, plants, and wood-derived materials, formulated with pharmaceutically or agriculturally acceptable carriers for administration to animals, plants, or soil.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing pesticidal and parasiticidal compounds are used, then some parasites and pests can be controlled, but resistance development occurs and effectiveness decreases against certain ectoparasites and endoparasites
Solution Approach 1:
The patent employs parameter changes by modifying the chemical structure of isoxazoline compounds through various substitutions at positions B1, B2, B3, P1, P2, Y, and Q. These structural parameter changes create novel compounds with improved biological activity and reduced resistance development while maintaining effectiveness against multiple parasite and pest types
Solution Approach 2:
The patent creates composite pesticidal and parasiticidal compounds by combining the isoxazoline core structure with various substituent groups and linkers. This composite approach generates molecules with enhanced versatility and effectiveness against both ectoparasites and endoparasites while overcoming resistance issues
2Reliability
If existing compounds are used to control parasites, then some parasitic infections can be treated, but they are ineffective against certain ectoparasites and endoparasites
Solution Approach 1:
The patent achieves universality by designing isoxazoline compounds with a core structure that can target multiple parasite types simultaneously. The compounds demonstrate broad-spectrum activity against ectoparasites (fleas, ticks, mites, lice) and endoparasites (nematodes, cestodes, trematodes) through their versatile molecular architecture and multiple interaction sites
3Productivity
If existing pesticidal agents are used, then some invertebrate pests can be controlled, but resistance to existing agents is a significant issue
Solution Approach 1:
The patent applies parameter changes by systematically varying the chemical parameters of isoxazoline compounds including substituents at B1, B2, B3 positions and linkers Q1, Q2, Q3. These parameter modifications produce compounds with novel mechanisms of action that maintain high pest control efficiency while minimizing resistance development
Data Source
AI summary
The present invention relates to pesticidal and parasiticidal isoxazoline of formula (I) and salts thereof:wherein variables B1, B2, B3, R1, P1, P2, Y and Q are described herein are as defined in the description. The invention also relates to parasiticidal and pesticidal compositions comprising the isoxazoline compounds of formula (I), processes for their preparation and their uses to prevent or treat parasitic infections or infestations in animals and as pesticides.