Isoxazoline Compounds for Invertebrate Pest Control
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Solution Overview
Problem
Current methods for controlling invertebrate pests in agronomic and nonagronomic environments are limited by the need for more effective, less toxic, and environmentally safer compounds with different sites of action, as existing products often have limitations in efficacy and safety.
Innovation Solution
Development of isoxazoline compounds of Formula 1' and their compositions for use in controlling invertebrate pests, which include specific structural variations and combinations with surfactants, solid diluents, and additional biologically active agents, applied to pests or their environments to inhibit pest development and growth.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing pest control products are used, then pest control function is provided, but efficacy and safety are limited with potential for bioaccumulation and environmental harm
Solution Approach 1:
The patent applies parameter changes by modifying the chemical structure of pest control compounds through specific isoxazoline core structures with varied substituents (R1-R6, R8-R12, R14-R18 groups). These structural parameter changes enable improved efficacy against invertebrate pests while reducing toxicity and environmental persistence compared to conventional pesticides. The systematic variation of molecular parameters allows optimization of the efficacy-safety profile.
Solution Approach 2:
The patent employs composite materials by combining the isoxazoline compound with multiple formulation components including surfactants (nonionic, anionic, cationic, amphoteric), adjuvants, and inert carriers. This composite formulation approach enhances the biological activity and environmental safety of the active ingredient while providing improved pest control performance and reduced environmental impact compared to pure chemical applications.
2Productivity
If higher doses of existing compounds are applied to improve efficacy, then pest control effectiveness increases, but toxicity and environmental impact increase
Solution Approach 1:
The patent achieves higher productivity at lower doses through parameter changes in the molecular structure of isoxazoline compounds. The optimized chemical structure provides enhanced biological activity and improved uptake/translocation properties, allowing effective pest control at reduced application rates. This reduces the total chemical load on the environment while maintaining or improving crop protection effectiveness.
Solution Approach 2:
The patent replaces the mechanical approach of increasing application volume/dose with a chemical mechanism substitution using novel isoxazoline structures that provide superior biological activity per unit dose. The compounds act through specific molecular mechanisms (inhibition of essential biological processes in invertebrates) that are more efficient than conventional contact toxins, reducing the need for high-dose applications.
3Reliability
If conventional pesticide formulations are used, then pest control is achieved, but rapid clearance and reduced bioaccumulation are not obtained
Solution Approach 1:
The patent applies parameter changes to achieve the desired balance between reliability and duration by modifying the chemical structure of isoxazoline compounds. The molecular design incorporates features that enable effective pest control while facilitating metabolic degradation and rapid clearance from vertebrate systems. The structural parameters are optimized to reduce persistence in the environment and minimize bioaccumulation potential while maintaining reliable pest control.
Solution Approach 2:
The patent embodies the discarding principle through the design of isoxazoline compounds that are metabolized and eliminated from biological systems rather than persisting. The compounds are designed to perform their pest control function and then be broken down into non-toxic metabolites that are excreted or degraded in the environment, preventing long-term accumulation and enabling sustainable use.
Data Source
AI summary
Disclosed are Compounds of Formula (1) or (1'), wherein Q is (Q-1) or (Q-2); and R1, R2, R3, J and X are as defined in the disclosure. Also disclosed are compositions containing the Compounds of Formula (1) or Formula (1') and methods for controlling an invertebrate pest comprising contacting the invertebrate pest or its environment with a biologically effective amount of a Compound or a composition of the invention.