Isoxazoline Solution Stabilized by Vitamin E in Sanitized Water
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Solution Overview
Problem
Current methods for treating parasite infestations in animals via drinking water are ineffective due to degradation of isoxazoline compounds when exposed to water sanitizers, leading to reduced efficacy and stability issues in pharmaceutical compositions.
Innovation Solution
Incorporating vitamin E into the pharmaceutical composition to prevent degradation of isoxazoline compounds in sanitised drinking water, ensuring long-term stability and effective distribution of the active parasiticidal compound.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If isoxazoline compounds are used in sanitised drinking water for parasite treatment, then effective parasite control is achieved, but the isoxazoline degrades rapidly reducing efficacy
Solution Approach 1:
Vitamin E acts as an intermediary substance that mediates between the isoxazoline compound and the sanitizer environment. It provides protective action against degradation while allowing the isoxazoline to maintain its parasiticidal activity, effectively shielding the active compound from harmful interactions with sanitizers in drinking water
2Stability of the object's composition
If vitamin E is added to protect isoxazoline from degradation, then stability and shelf-life are improved, but formulation complexity increases
Solution Approach 1:
The invention changes the chemical composition parameters of the pharmaceutical formulation by incorporating vitamin E at specific concentrations (0.01-10% w/v). This parameter modification fundamentally alters the stability profile of the isoxazoline compound in sanitised drinking water, extending shelf-life to at least 18 months while maintaining parasiticidal efficacy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of vitamin E effectively protects isoxazoline from degradation in sanitised drinking water, maintaining its availability and efficacy for up to 24 hours and extending the shelf-life of the pharmaceutical composition to at least 18 months, providing a stable and effective solution for parasite control in animals.
Implementation Method 1
stabilisation of an isoxazoline in medicated drinking water comprising a water sanitizer
Data Source
AI summary
For the prevention of parasite infestation of animals, an isoxazoline can be administered by drinking water route. However the inventors have found that when the drinking water is sanitized, for instance by using hypochlorite, the isoxazoline becomes degraded. Surprisingly, the isoxazoline can be protected from degradation by the use of a vitamin E. A pharmaceutical composition can now be prepared containing a concentrated solution of the isoxazoline in a solvent and co-solvent, with vitamin E. The composition can be diluted in drinking water, even when sanitized, to prepare medicated drinking water for animals. This way an anti-parasitic treatment can be mass-administered, leading to a highly effective reduction of the parasite infestation of an animal, and its surroundings.