Ivermectin Cream-Gel Using Non-Surfactant Emulsifier
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Solution Overview
Problem
Current pharmaceutical compositions containing ivermectin for dermatological conditions, particularly rosacea, lack stability, cosmetic acceptability, and optimal skin penetration, with existing formulations either being unstable or not suitable for sensitive skin.
Innovation Solution
Development of ivermectin-based cream-gel compositions using a non-surfactant polymeric emulsifier to disperse an oily phase with oils having a melting point below 30°C, free of solid fats, which provides a stable, non-greasy, and easily spreadable formulation that enhances skin penetration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If conventional emulsifiers (surfactants) are used to disperse the oily phase in aqueous phase, then emulsion stability is improved, but skin sensitivity and cosmetic acceptability deteriorate
Solution Approach 1:
The patent uses non-surfactant polymeric emulsifiers as intermediaries to stabilize the emulsion without the harmful effects of conventional surfactants. These polymers act as mediators between the oily phase and aqueous phase, providing stability through steric stabilization rather than surface tension reduction, thereby avoiding skin irritation while maintaining emulsion integrity
Solution Approach 2:
The patent changes the fundamental parameter of emulsifier type from surfactant-based to polymer-based emulsification. This parameter change transforms the mechanism of emulsion stabilization from interfacial tension reduction to steric stabilization, eliminating the harmful effects of surfactants on sensitive skin while maintaining physical stability
2Stability of the object's composition
If solid fats with melting point above 30°C are included in the oily phase, then formulation stability is improved, but spreadability and cosmetic feel deteriorate
Solution Approach 1:
The patent changes the melting point parameter of the oily phase components to below 30°C, ensuring all fats and oils remain liquid at skin temperature. This parameter change eliminates the need for solid fats that would compromise spreadability, while formulation stability is maintained through the optimized combination of liquid oils and non-surfactant polymeric emulsifiers
3Quantity of substance
If ivermectin concentration is increased to improve treatment efficacy, then therapeutic effect is improved, but skin penetration and bioavailability deteriorate
Solution Approach 1:
The patent changes the physical state and composition parameters of the formulation base (using liquid oils with melting point below 30°C and non-surfactant polymeric emulsifiers) to create a matrix that enhances ivermectin penetration. This parameter change in the formulation vehicle improves bioavailability and skin penetration, allowing effective treatment at optimized concentrations without requiring excessive amounts of the active ingredient
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The cream-gel formulation offers improved stability, comfort, and enhanced bioavailability of ivermectin, ensuring effective treatment of rosacea with improved skin penetration and prolonged shelf-life.
Implementation Method 1
an oily phase dispersed in an aqueous phase by means of a non-surfactant polymeric emulsifier
Data Source
AI summary
Pharmaceutical cream-gel compositions useful for the treatment of a variety of dermatological conditions, disorders and afflictions, in particular of rosacea, contain at least one avermectin compound active principle, and which also contain an oily phase dispersed in an aqueous phase by means of a non-surfactant polymeric emulsifier, the oily phase comprising oils having a melting point below 30° C. and being free of solid fats having a melting point above 30° C., formulated into a physiologically acceptable medium therefor.