Ivermectin Feed Premix Stabilization via pH Control
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Avermectin and milbemycin compounds in animal feed premixes are susceptible to acid and base catalyzed decomposition, leading to reduced shelf life, which affects their stability and efficacy in treating parasitic infestations in swine and horses.
Innovation Solution
The formulation of a stabilized premix feed with a controlled amount of pharmaceutically acceptable stabilizers to adjust the pH range of 4 to 6, incorporating surfactants, waxes, antioxidants, and carrier vehicles, which prevents or decreases the formation of degradates, thereby extending the shelf life of avermectin and milbemycin derivatives.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If stabilizers are incorporated into the premix formulation, then the shelf life of avermectin and milbemycin compounds is extended, but the formulation complexity increases
Solution Approach 1:
The patent applies parameter changes by adjusting the pH of the premix formulation to a specific range (pH 2-4) through controlled incorporation of stabilizers. This pH adjustment prevents acid and base catalyzed decomposition of avermectin and milbemycin compounds, thereby extending their shelf life while maintaining a relatively simple formulation approach
Solution Approach 2:
The patent uses stabilizers as intermediary substances that mediate between the active ingredients (avermectin and milbemycin compounds) and the feed matrix. These stabilizers create a protective chemical environment that prevents degradation without requiring complex formulation structures
2Reliability
If the amount of stabilizer is increased to adjust pH to 4-6, then decomposition of active ingredient is prevented, but the cost of formulation increases
Solution Approach 1:
The patent optimizes the stabilizer quantity by precisely controlling the pH parameter within the range of 2-4. This parameter-based approach ensures sufficient stabilization of active ingredients while avoiding excessive stabilizer addition, thereby balancing reliability with cost-effectiveness
Solution Approach 2:
The patent applies partial action by incorporating stabilizers only to the extent necessary to achieve the target pH range (pH 2-4), rather than using excessive amounts. This partial stabilization approach is sufficient to prevent decomposition while minimizing stabilizer usage and associated costs
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution effectively extends the shelf life of avermectin and milbemycin compounds by reducing degradate formation, maintaining their stability and efficacy for parasite control in swine and horses, with improved storage stability over 9 to 18 months.
Implementation Method 1
controlling the amount of an already existing pharmaceutically or veterinary acceptable stabilizer in the premix in an amount effective to adjust the pH range to between about 4 to about 6
Implementation Method 2
decrease or to prevent the acid or base catalyzed decomposition in the premix of the avermectin or milbemycin compound
Implementation Method 3
decrease or to prevent the acid or base catalyzed decomposition in the premix of the avermectin or milbemycin compound
Data Source
AI summary
The invention relates to a stabilized premix feed or feed-like formulation that has an extended shelf life due to a decrease of the degradates of the active ingredient by controlling the amount of an already existing stabilizer in the formulation. The feed premix is used in the treatment of parasites in mammals, in particular swine and horses. The invention further relates to a method to extend the shelf life of a stable premix feed or feed-like formulation for the treatment of parasite infestation in swine and horses comprising controlling the amount of an already existing antioxidant or stabilizer in the formulation to decrease or to prevent the formation of acid/base catalyzed decomposition of the active ingredient.