Chlorophyll-Free Jambu Extract via Selective Hydrolysis
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Solution Overview
Problem
Current methods for isolating spilanthol from jambu extract are inefficient and costly, and there is no process for obtaining a chlorophyll-free jambu extract without concomitant hydrolysis of spilanthol, limiting the commercial value and cosmetic applications of the extract.
Innovation Solution
A selective basic hydrolysis process involving mixing ground jambu with alcohol, adding a strong base, heating, filtering, and using aluminum sulfate to separate chlorophyll from spilanthol, followed by solvent extraction and evaporation, which preserves the spilanthol content and removes chlorophyll effectively.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If conventional isolation methods are used to obtain spilanthol from jambu extract, then spilanthol can be isolated, but the process is inefficient and costly
Solution Approach 1:
The patent applies parameter changes by optimizing the basic hydrolysis conditions (pH, temperature, time) to selectively hydrolyze chlorophyll while preserving spilanthol. By controlling these parameters, the process achieves efficient separation of chlorophyll from spilanthol, improving isolation efficiency while reducing costs through a simplified process that avoids complex chromatography or multiple extraction steps
2Object-affected harmful factors
If basic hydrolysis is used to remove chlorophyll, then chlorophyll is effectively removed, but spilanthol may undergo concomitant hydrolysis
Solution Approach 1:
The patent applies local quality by creating different chemical environments for chlorophyll and spilanthol during basic hydrolysis. The process conditions (controlled pH around 8-9, specific temperature range, limited reaction time) are optimized to make the hydrolysis reaction selective for chlorophyll esters while leaving spilanthol amide bonds intact. This selective action removes chlorophyll effectively while preserving spilanthol integrity
Solution Approach 2:
The patent uses parameter changes to control the selectivity of basic hydrolysis. By adjusting pH to alkaline conditions (pH 8-9), temperature to moderate ranges (40-60°C), and controlling reaction time, the process achieves selective hydrolysis of chlorophyll without significant degradation of spilanthol. These parameter optimizations ensure reliable spilanthol preservation while achieving effective chlorophyll removal
3Quantity of substance
If chlorophyll is present in the jambu extract, then the extract contains all natural components, but the cosmetic appeal and commercial value are reduced
Solution Approach 1:
The patent applies the extraction principle by selectively removing chlorophyll from the jambu extract through basic hydrolysis followed by separation techniques. The process extracts and isolates chlorophyll as a separate phase or precipitate, leaving behind a chlorophyll-free spilanthol-rich extract. This selective removal enhances cosmetic appeal by eliminating the green coloration while preserving all other beneficial natural components, thereby increasing commercial value
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process achieves a high spilanthol content of up to 28.7% in the extract, reducing production costs and enhancing the cosmetic appeal by removing chlorophyll, making it suitable for various cosmetic compositions without affecting spilanthol's properties.
Implementation Method 1
selective basic hydrolysis of chlorophyll
Implementation Method 2
adding aqueous aluminum sulfate to the filtered mixture obtained in (d) and stirring
Implementation Method 3
adding to the alcohol/water solution obtained in (g) an organic solvent selected from hexane or other organic solvent that exhibits a polarity similar to hexane
Implementation Method 4
filtering the solution and evaporating the organic solvent
Data Source
Figure 1
AI summary
The present invention discloses a process of preparing jambu extract that results in a jambu extract free from chlorophyll and derivatives of this compound. It is a method for isolating the components of interest in a simplified way, with quite high process yield, higher than 85%. The present invention further relates to the use of this extract in preparing cosmetic compositions, the cosmetic compositions comprising said extract, and to cosmetic products comprising said cosmetic compositions.