Jambu Extract Purification via Selective Basic Hydrolysis
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Solution Overview
Problem
Current methods for isolating spilanthol from jambu (Spilanthes oleracea) do not effectively remove chlorophyll, leading to inefficient processes and high production costs, with no established techniques for obtaining chlorophyll-free jambu extract using selective basic hydrolysis without concomitant hydrolysis of spilanthol.
Innovation Solution
A process involving mixing ground jambu with alcohol and a strong base, heating, filtering, and using an aqueous electrolyte solution to achieve selective basic hydrolysis of chlorophyll, separating it from spilanthol, which is then purified with an organic solvent and drying agent, resulting in a high-yield, cost-effective jambu extract with up to 28.7% spilanthol content.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Manufacturing precision
If conventional methods are used to isolate spilanthol from jambu, then spilanthol can be obtained, but chlorophyll is not effectively removed leading to inefficient processes and high production costs
Solution Approach 1:
The invention changes the chemical parameters by introducing a strong base (NaOH or KOH) to create selective basic hydrolysis conditions. This chemical parameter change transforms chlorophyll into water-soluble derivatives while leaving spilanthol intact in the organic phase, achieving separation based on solubility parameter differences.
Solution Approach 2:
The invention extracts and removes chlorophyll from the jambu extract by converting it into water-soluble derivatives through basic hydrolysis. The chlorophyll derivatives are then separated into the aqueous phase, effectively taking out the unwanted component while retaining spilanthol in the organic phase.
2Manufacturing precision
If chlorophyll is removed from jambu extract, then commercial appeal is enhanced, but conventional removal processes involve multiple steps and expensive reactants
Solution Approach 1:
The invention merges the extraction and chlorophyll removal operations into a single integrated process. The strong base treatment simultaneously serves to hydrolyze chlorophyll and facilitate its separation, combining multiple functions into one operation and eliminating the need for separate removal steps.
Solution Approach 2:
The invention uses a simple parameter change (adding strong base) to trigger selective hydrolysis of chlorophyll. This single parameter change initiates a cascade of effects that lead to chlorophyll removal, simplifying the overall process from multiple complex steps to a single treatment step.
3Manufacturing precision
If selective basic hydrolysis is applied to remove chlorophyll, then chlorophyll-free extract is obtained, but there is risk of concomitant hydrolysis of spilanthol
Solution Approach 1:
The invention applies local quality by creating selective reaction conditions that affect only specific components. The strong base selectively hydrolyzes chlorophyll esters while leaving spilanthol amide bonds intact, achieving local chemical modification of only the target molecule based on differences in chemical reactivity.
Solution Approach 2:
The invention controls the reliability by precisely managing reaction parameters (base concentration, temperature, time) to achieve selective hydrolysis. By optimizing these parameters, the process selectively targets chlorophyll while preserving spilanthol, demonstrating parameter-controlled selectivity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The process yields a high spilanthol content jambu extract efficiently, maintaining spilanthol's fat-solubility and removing chlorophyll, enabling the production of cosmetic compositions with enhanced commercial appeal and effectiveness, while reducing production costs.
Implementation Method 1
adding a strong base, heating the mixture obtained in (b) up to a temperature of about 65° C. The process yields a high spilanthol content jambu extract efficiently, maintaining spilanthol's fat-solubility and removing chlorophyll
Implementation Method 2
adding to the alcohol:water solution obtained in (g) an organic solvent soluble in spilanthol at a proportion ranging from 1:1:0.25 to 1:1:2 in terms of volume
Implementation Method 3
adding a drying agent, filtering the solution and evaporating the organic solvent
Implementation Method 4
heating the mixture obtained in (b) up to a temperature of about 65° C.
Data Source
AI summary
The present invention discloses a process of preparing jambu extract that results in a jambu extract free from chlorophyll and derivatives of this compound. It is a method for isolating the components of interest in a simplified way, with quite high process yield, higher than 85%. The present invention further relates to the use of this extract in preparing cosmetic compositions, the cosmetic compositions comprising said extract, and to cosmetic products comprising said cosmetic compositions.