Java Ginger Extract Dimer Enrichment via Thermal Diels-Alder
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Solution Overview
Problem
Current Java ginger extracts have a low content of phenyl butenoid dimer, which limits their effectiveness in exerting neurotrophic factor-like actions for treating neurogenic diseases such as Alzheimer's and Parkinson's, due to the difficulty in increasing the dimer content through existing methods.
Innovation Solution
The process involves thermally transforming phenyl butenoid monomers in Java ginger extracts to increase the content of phenyl butenoid dimer, using heating or sunlight exposure to promote the Diels-Alder reaction, resulting in a higher D/M ratio and reduced odor, thereby enhancing the extract's efficacy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional solvent extraction methods are used to prepare Java ginger extract, then the extraction process is simple and straightforward, but the content of phenyl butenoid dimer remains extremely low compared to the monomer
Solution Approach 1:
The patent applies parameter changes by adjusting the extraction solvent composition (using specific ratios of water and organic solvent), controlling extraction temperature (40-80°C), and setting extraction time (2-24 hours) to optimize the conversion of monomer to dimer during extraction, thereby increasing phenyl butenoid dimer content while maintaining process simplicity
Solution Approach 2:
The patent employs preliminary action by pre-heating the extraction solvent before use and conducting the extraction process under controlled conditions that promote in-situ conversion of monomer to dimer during extraction, rather than extracting first and then converting separately
2Quantity of substance
If the intake of conventional Java ginger extract is increased to achieve effective NGF-like action, then the NGF-like effect can be reached, but the specific odor becomes more pronounced and intake volume increases
Solution Approach 1:
The patent changes the chemical composition parameters by optimizing extraction conditions to increase the dimer-to-monomer ratio. Since the dimer has weaker odor than the monomer, this parameter change reduces the specific odor while maintaining or enhancing the NGF-like activity at lower intake levels
3Manufacturing precision
If existing extraction methods are used, then the extraction process is straightforward, but the D/M ratio (dimer to monomer ratio) remains low and efficacy is limited
Solution Approach 1:
The patent achieves precise control of the D/M ratio by adjusting extraction parameters including solvent composition (water-organic solvent ratio), temperature (40-80°C), and time (2-24 hours). These parameter changes enable manufacturing of extract with optimized D/M ratio while keeping the process relatively simple and scalable
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The resulting Java ginger extract with a higher phenyl butenoid dimer content is more effective in treating neurogenic diseases, requiring lower intake and expanding application scope, while maintaining safety and reducing odor, thus serving as a prophylaxis and treatment for conditions like Alzheimer's and Parkinson's.
Implementation Method 1
a phenyl butenoid monomer was transformed into the phenyl butenoid dimer by heating the solute
Implementation Method 2
by heating the solute, and completed the present invention
Implementation Method 3
heating or sunlight exposure to promote the Diels-Alder reaction
Data Source
AI summary
The present invention relates to a Java ginger extract which is prepared from Java ginger as a starting material and aimed at a concentrate as an objective (concentrate including solid matter) obtained from a solute. The starting material or the products on any of the steps in which the objective is manufactured from the starting material is heated or exposed to sunlight. In relation to a peak area ratio on high-performance liquid chromatography (HPLC), the peak area ratio (D/M ratio) of a phenyl butenoid dimer represented by the following formula (1) to a monomer represented by the following formula (2) is 0.6 or higher. An intake/dose of the Java ginger extract can be decreased by increasing a content of a phenyl butenoid dimer with an NGF-like action.