Jet Injection Electroporation Device for Skin Delivery
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Solution Overview
Problem
There is a need for a portable, hand-held device that can effectively deliver an agent via needle-free jet injection and subsequently electroporate, combining these functions in a single self-contained unit for medical treatment.
Innovation Solution
The device includes a housing with a nozzle and electrodes, a propulsion cartridge, and a power supply, allowing for the delivery of a pre-measured dose of agent through jet injection and electroporation using a combination of mechanical and electrical mechanisms, including a trigger assembly and propulsion spring, to facilitate both jet injection and electroporation in a single portable device.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If jet injection and electroporation are performed using separate devices, then each device can be optimized for its specific function, but the overall treatment process becomes complex and requires multiple devices
Solution Approach 1:
The patent combines jet injection and electroporation functions into a single integrated device. The housing contains both the nozzle for jet injection and the electrode array for electroporation, allowing both functions to be performed in one device rather than requiring separate devices.
Solution Approach 2:
The device is designed to perform multiple functions: jet injection delivery, electroporation treatment, and integrated control. The single device serves as both an injection device and an electroporation device, eliminating the need for separate equipment.
2Ease of operation
If a portable hand-held device is designed to combine jet injection and electroporation, then portability and ease of use are improved, but the device size and power requirements increase
Solution Approach 1:
The electrode array is retractably mounted within the housing, allowing it to be stored compactly during transport and deployed only when needed. The electrodes nest within the housing volume, reducing the device's external dimensions when not in use.
Solution Approach 2:
The electrode array transitions from a retracted state during transport to an extended operational state during treatment. This dynamic configuration allows the device to maintain a compact form factor while providing full functionality when needed.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution enables efficient and effective delivery of agents into the skin, enhancing immune responses by combining jet injection and electroporation, as demonstrated by higher antibody responses in immunization studies compared to traditional methods.
Implementation Method 1
a propulsion spring extending between the propulsion rod and the housing, the propulsion spring configured to bias the propulsion rod toward the deployed position
Implementation Method 2
Electroporation is the use of a transmembrane electric field pulse to induce microscopic pathways (pores) in a bio-membrane
Data Source
AI summary
A jet injection and electroporation device for use with an agent cartridge defining a volume containing a pre-measured dose of agent therein, the electroporation device including a housing having an axis extend therethrough, a nozzle at least partially positioned within the housing, and a cavity sized to receive at least a portion of the agent cartridge therein. The device also includes an array having a plurality of electrodes extending therefrom, a propulsion cartridge configured to operatively engage the cartridge when the agent cartridge is positioned within the cavity; and a power supply in electrical communication with the array.