Jet Injection Testosterone Delivery for Steady Plasma Levels

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Solution Overview

Problem

Conventional methods of administering testosterone, such as hypodermic injections and transdermal creams, are painful, inconvenient, and lead to issues like polycythemia, skin irritation, and inadequate testosterone levels, while transdermal methods are expensive and have poor compliance.

Innovation Solution

A method of administering testosterone using powered injectors, including autoinjectors and needle-free jet injectors, that deliver the hormone rapidly and remotely from the needle tip, minimizing leak-back and ensuring steady state blood concentration through repeated dosing and titration to the lowest effective dose.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If hypodermic injections are used to administer testosterone, then testosterone delivery is effective, but the method causes pain and increases risk of polycythemia

Engineering Contradiction:

Improvetestosterone delivery effectivenessVSAvoidpain and polycythemia risk

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent replaces the mechanical hypodermic injection system with a jet injection system that uses high-velocity fluid dynamics to deliver testosterone. The jet injector propels medication through a narrow nozzle at high speed, penetrating skin without a traditional needle and depositing medication deeper in tissue, thereby eliminating needle-related pain and reducing polycythemia risk while maintaining effective testosterone delivery

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

2Ease of operation

If transdermal creams, gels and patches are used to administer testosterone, then the method is convenient, but it causes skin irritation and acne at the site of administration

Engineering Contradiction:

Improveconvenience of administrationVSAvoidskin irritation and acne

Core Design Contradiction:

Ease of operationVSObject-affected harmful factors

Solution Approach 1:

The patent replaces transdermal absorption methods with jet injection technology that delivers testosterone directly into subcutaneous or intramuscular tissue. This bypasses the epidermis and dermis layers that cause irritation and acne when testosterone is applied topically, while maintaining convenient administration through a rapid, single-step injection process

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Ease of operation

If transdermal methods are used to administer testosterone, then the method is easy to use, but it has poor compliance with daily administration

Engineering Contradiction:

Improveease of useVSAvoidcompliance with daily administration

Core Design Contradiction:

Ease of operationVSProductivity

Solution Approach 1:

The patent implements periodic jet injection administration of testosterone at optimized intervals (e.g., weekly, bi-weekly, or monthly depending on formulation). This periodic dosing schedule, delivered through rapid jet injection, maintains steady testosterone levels while requiring far fewer administrations than daily transdermal methods, thereby dramatically improving patient compliance and adherence

Inventive Principle:

Principle #19Periodic action

4Ease of operation

If transdermal creams, gels and patches are used to administer testosterone, then the method is simple, but it fails to provide some patients with adequate testosterone levels

Engineering Contradiction:

Improvesimplicity of methodVSAvoidadequacy of testosterone levels

Core Design Contradiction:

Ease of operationVSReliability

Solution Approach 1:

The patent replaces transdermal delivery with jet injection that penetrates directly through the skin barrier into deeper tissue compartments. This mechanical delivery method ensures adequate testosterone levels by bypassing the limited absorption capacity of transdermal methods, achieving reliable therapeutic concentrations in all patients regardless of skin condition or absorption variability

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The patent utilizes parameter changes in the jet injection system, including adjustable medication pressure, nozzle diameter, and injection depth, to optimize testosterone delivery. These parameter adjustments ensure adequate drug delivery to various tissue types and patient anatomies, achieving reliable therapeutic levels that transdermal methods cannot consistently provide

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The method provides efficient, pain-free, and reliable testosterone delivery with minimal skin exposure and leak-back, achieving consistent blood plasma levels and improved patient compliance.

Implementation Method 1

needle-free jet injectors that deliver the hormone rapidly and remotely from the needle tip

Methodology Applied

Scientific EffectJet injection: Jet

Data Source

PatentUS20260102409A1Administration of testosterone compositions

Publication Date: 2026.04.16 ANTARES PHARMA INC

AI summary

The present invention provides compositions and methods for treating a subject in need of treatment with testosterone, including introducing testosterone into the subject subcutaneously, intradermally, or intramuscularly, from a needle assisted jet injection device.