JULGI Protein G-Quadruplex Diagnostic Composition
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods lack effective solutions for diagnosing and treating neurodegenerative diseases, cancer, and viral infection diseases related to abnormal guanine-quadruplex (G-quadruplex) formation or dissociation.
Innovation Solution
A guanine-quadruplex detecting composition comprising a JULGI protein or a protein with 80% or higher homology to JULGI, which binds to G-rich sequences and G-quadruplex structures, is used for diagnosis and treatment. This includes a diagnostic kit, a method for measuring protein activity in biological samples, and pharmaceutical compositions for preventing or treating diseases.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional diagnostic methods are used for neurodegenerative diseases and cancer, then general disease detection is possible, but detection precision for G-quadruplex-related diseases is insufficient
Solution Approach 1:
The patent introduces a JULGI protein as an intermediary substance that specifically binds to G-quadruplex structures. This protein serves as a mediator between the target G-quadruplex DNA/RNA structures and detection systems, enabling precise detection of G-quadruplex-related diseases through its specific binding activity while maintaining adaptability across different disease types.
Solution Approach 2:
The patent utilizes changes in binding parameters (binding affinity, binding specificity) of the JULGI protein to G-quadruplex structures under different physiological conditions to detect disease states. By measuring binding强度 and specificity under varying conditions, the system achieves high detection precision for G-quadruplex-related pathologies.
2Reliability
If no specific treatment methods are available for neurodegenerative diseases, then symptom management is possible, but effective treatment cannot be provided
Solution Approach 1:
The patent extracts and utilizes the specific binding function of the JULGI protein to G-quadruplex structures as a therapeutic mechanism. By isolating this specific protein-G-quadruplex interaction, the invention creates a targeted treatment approach that can specifically address G-quadruplex-related pathologies without requiring complex multi-component treatment systems.
3Measurement precision
If general disease detection methods are used, then broad disease screening is possible, but diagnostic precision for G-quadruplex-related diseases is insufficient
Solution Approach 1:
The JULGI protein serves as a simple yet highly specific intermediary that bridges G-quadruplex structures and detection systems. This single protein component provides high diagnostic precision through its specific binding activity while keeping the overall diagnostic system relatively simple and易于实施.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The JULGI protein effectively binds to G-quadruplex structures, providing a diagnostic tool for identifying diseases related to these structures and offering therapeutic potential for neurodegenerative diseases, cancer, and viral infections.
Implementation Method 1
a guanine-quadruplex (G-quadruplex) detecting composition including a JULGI protein or a protein having a homology of 80% or higher with the JULGI protein
Data Source
AI summary
The present disclosure relates to a use of JULGI in diagnosing and treating guanine quadruplex-related disease and, more particularly, to a guanine-quadruplex (G-quadruplex) detecting composition comprising JULGI protein or a protein having a homology of 80% or higher to the JULGI protein, a diagnostic composition comprising the detecting composition, a diagnostic kit comprising the diagnostic composition, a method for providing information for diagnosis of a neurodegenerative disease, cancer, or a viral infection disease which are in pathological correlation with G-quadruplex, and a pharmaceutical composition for prevention or treatment of a neurodegenerative disease, cancer, or a viral infection disease, the pharmaceutical composition comprising JULGI protein, a protein having a homology of 80% or more with the JULGI protein, or a mutant protein thereof. Thanks to the activity of binding to the G-quadruplex structure, JULGI according to the present disclosure is expected to be advantageously used in diagnosing or treating various diseases that are in pathological correlation with the abnormal formation and dissociation of the G-quadruplex structure.