JUP Biomarker Plasma Detection for Reproductive Tract Diagnosis
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Solution Overview
Problem
Current methods for diagnosing and predicting the development, progression, and outcome of diseases or disorders of the female reproductive tract, such as ovarian cancer and endometriosis, are invasive, lack sensitivity and specificity, and do not provide early detection capabilities.
Innovation Solution
A method involving the determination of the protein level of the biomarker JUP in a sample, either alone or in combination with other biomarkers, to diagnose and predict disease-related parameters in the female reproductive tract.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If invasive diagnostic methods (laparoscopy, biopsy) are used to diagnose diseases of the female reproductive tract, then diagnostic accuracy is improved, but patient comfort and ease of operation deteriorate
Solution Approach 1:
The patent uses plasma as an intermediary medium to detect disease biomarkers. Instead of directly examining tissue through invasive procedures, the method analyzes plasma samples containing disease-related proteins and biomarkers, providing accurate diagnosis without surgical intervention
Solution Approach 2:
The patent replaces mechanical invasive diagnostic systems (surgical instruments, biopsy tools) with biochemical detection methods. By measuring protein levels and biomarker concentrations in plasma samples through laboratory assays, the method achieves diagnostic accuracy without mechanical tissue sampling
2Reliability
If current diagnostic methods are used for early detection of ovarian cancer and endometriosis, then disease parameters can be assessed, but sensitivity and specificity are insufficient
Solution Approach 1:
The patent measures multiple biochemical parameters simultaneously in plasma samples, including protein levels, biomarker concentrations, and their ratios. This multi-parameter approach enhances both sensitivity and specificity for early disease detection compared to single-marker methods
Solution Approach 2:
The patent employs a composite diagnostic approach by analyzing multiple biomarkers and protein indicators together rather than in isolation. The combination of different biochemical markers creates a more reliable diagnostic profile that improves detection accuracy for early-stage diseases
3Loss of information
If invasive procedures are performed for diagnosis and monitoring, then disease development and progression can be examined, but the complexity and risk of the procedure increase
Solution Approach 1:
The patent extracts disease information from plasma samples rather than requiring extraction of tissue samples through surgery. By isolating and measuring biomarkers in the liquid plasma medium, the method obtains comprehensive disease parameters through a simple blood draw procedure
Data Source
AI summary
The invention relates to methods for diagnosing, predicting disease development, disease progression and/or disease outcome, predicting susceptibility to treatment and/or classification in the context of a disease or disorder of the female reproductive tract, wherein JUP alone or in combination with further biomarkers is determined. The invention further relates to pharmaceutical products for use inpatients stratified according to the methods of the invention and to compositions comprising reagents for the detection of the biomarker JUP or of the biomarker JUP and further biomarkers for the diagnosis of a disease or disorder of the female reproductive tract.