Justicia Secunda Extract Composition for Drug-Resistant Bacteria

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Solution Overview

Problem

Bacterial strains such as MRSA, VRE, and DRSP have developed resistance to conventional antibacterial drugs like ciprofloxacin, minocycline, and vancomycin, necessitating the need for novel pharmaceutical compositions effective against these resistant strains.

Innovation Solution

Preparation of antibacterial compositions from the plant Justicia secunda involves drying and pulverizing its leaves and stems, extracting with organic solvents, and purifying through column chromatography to yield potent antibacterial powders effective against resistant bacteria.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If existing antibacterial drugs (ciprofloxacin, minocycline, vancomycin) are used, then treatment of susceptible bacterial infections is effective, but treatment of resistant bacterial infections (MRSA, VRE, DRSP) fails due to increasing antimicrobial resistance

Engineering Contradiction:

Improveeffectiveness against resistant bacterial strainsVSAvoidbacterial resistance to existing drugs

Core Design Contradiction:

ReliabilityVSAdaptability or versatility

Solution Approach 1:

The patent changes the chemical composition parameters by using organic solvent extracts from Justicia secunda plant, which contains different chemical compounds compared to conventional antibacterial drugs. This parameter change enables the extract to overcome bacterial resistance mechanisms that have developed against traditional antibiotics, thereby restoring effectiveness against resistant strains while maintaining broad-spectrum activity

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The organic solvent extract from Justicia secunda represents a composite material containing multiple phytochemical compounds working synergistically. This composite approach differs from single-molecule conventional antibiotics and provides enhanced effectiveness against resistant bacterial strains through multiple modes of action, addressing the adaptability issue of bacterial resistance

Inventive Principle:

Principle #40Composite materials

2Reliability

If novel antibacterial agents are developed to overcome resistance, then effectiveness against resistant strains improves, but development complexity and time increase

Engineering Contradiction:

Improveeffectiveness against resistant bacterial strainsVSAvoidcomplexity of novel drug development

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent applies extraction by using organic solvents to extract active antibacterial compounds directly from the Justicia secunda plant material. This extraction approach provides a ready-made complex of active compounds that can be processed into pharmaceutical compositions, significantly reducing the complexity and time required compared to de novo synthesis of novel antibacterial agents while maintaining effectiveness against resistant strains

Inventive Principle:

Principle #2Taking out (Extraction)

3Reliability

If plant extracts are used as antibacterial agents, then novel activity against resistant strains is achieved, but manufacturing and purification processes become more complex

Engineering Contradiction:

Improveantibacterial activity against resistant strainsVSAvoidease of extract preparation and purification

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent applies segmentation by dividing the plant material into processed components through systematic steps: drying, pulverization, extraction with organic solvents, and column chromatography purification. This segmented approach transforms raw plant material into standardized pharmaceutical compositions with controlled purity and potency, making the manufacturing process more manageable and scalable while preserving the antibacterial activity against resistant strains

Inventive Principle:

Principle #1Segmentation

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The compositions demonstrate broad-spectrum antibacterial activity, including efficacy against MRSA, VRE, and DRSP, often surpassing the activity of existing drugs.

Implementation Method 1

an organic solvent, the coarse powder combined with the organic solvent for one to ten days, but preferably seven days, to form an organic solvent extract

Methodology Applied

Scientific EffectSolvation: Solvation

Implementation Method 2

the organic solvent extract that yields a powder composition under column chromatography

Methodology Applied

Scientific EffectChromatography: Chromatography

Data Source

PatentUS12629400B2Pharmaceutical compositions and methods for treating or preventing bacterial infections in humans and in animals

Publication Date: 2026.05.19 LAGRAY INC

AI summary

A pharmaceutical composition having antibiotic qualities is disclosed. The pharmaceutical composition includes a plurality of leaves and stems of the plant Justicia secunda, wherein the plurality of leaves and stems dried and pulverized to form a coarse powder; and an organic solvent, the coarse powder combined with the organic solvent for one to ten days, but preferably seven days, to form an organic solvent extract that yields a powder composition under column chromatography.