JWA Gene Activator Compound for Anti-Aging and Homeostasis
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Solution Overview
Problem
There are no small molecule compounds reported to activate the expression of the JWA gene in vivo for anti-aging effects, which are crucial for treating aging-related diseases such as atherosclerosis and type 2 diabetes.
Innovation Solution
Development of a compound, represented by formula (I) or its pharmaceutically acceptable salts, which activates the JWA gene expression to provide anti-aging effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If no small molecule compounds are used to activate JWA gene expression, then the complexity of the solution remains low, but anti-aging effects cannot be achieved
Solution Approach 1:
The patent applies parameter changes by modifying molecular structure parameters to create compound (I) with specific structural features that enable JWA gene activation. The compound contains a core structure with substituents at specific positions (R1-R6 groups) that tune the molecular properties to achieve the desired biological effect of activating JWA gene expression and providing anti-aging effects.
2Reliability
If compound (I) is used to activate JWA gene expression, then anti-aging effects are achieved, but the manufacturing complexity increases
Solution Approach 1:
The patent applies segmentation by dividing the complex molecular structure into modular components with substituents R1-R6 that can be independently optimized and synthesized. This modular approach allows for systematic synthesis and manufacturing of the compound while maintaining the core structure necessary for JWA gene activation.
3Reliability
If JWA gene expression is activated to treat aging-related diseases, then disease treatment efficacy improves, but the specificity of the compound increases
Solution Approach 1:
The patent applies local quality by introducing specific substituents at defined positions (R1-R6) on the core molecular structure to enhance the compound's specificity for JWA gene activation. These localized structural modifications improve the compound's ability to selectively activate JWA gene expression and treat aging-related diseases while maintaining overall structural integrity.
Data Source
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AI summary
Provided are an anti-aging use of JWA gene and a related compound. The JWA gene has a GenBank Accession Number of AF070523. The JWA gene and JWA protein can be used as target of anti-aging, treatment of aging related diseases, anti-oxidation, maintaining homeostasis. Formula I compound is for use in manufacture of products for anti-aging, or treatment of aging related diseases, or maintaining homeostasis.