Kaempferol Analog Composition for Oxygen Consumption Efficiency

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Solution Overview

Problem

Current compositions fail to effectively enhance oxygen consumption efficiency and reduce fatigue and breathlessness, especially during strenuous activities and in individuals with declining oxygen states due to aging or other factors.

Innovation Solution

A composition containing a kaempferol analog or its glycoside, administered orally, which improves oxygen consumption efficiency, reduces fatigue, and enhances dynamic/kinetic visual acuity by increasing endurance and reducing breathlessness across various exercise intensities.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Productivity

If conventional compositions are used, then basic nutritional needs are met, but oxygen consumption efficiency cannot be improved and fatigue is not reduced

Engineering Contradiction:

Improveoxygen consumption efficiencyVSAvoideffectiveness under hypoxic conditions

Core Design Contradiction:

ProductivityVSReliability

Solution Approach 1:

The patent changes the chemical parameter by introducing specific kaempferol analog structures with modified hydroxyl and methoxyl group positions (Formula I with specific R1-R6 substitutions). This structural parameter change enables the compound to effectively improve oxygen consumption efficiency and reduce fatigue, resolving the contradiction between basic nutritional supplementation and active oxygen metabolism enhancement.

Inventive Principle:

Principle #35Parameter changes

2Speed

If intense exercise is performed, then physical activity efficiency is tested, but arterial oxygen saturation decreases to 93-88%

Engineering Contradiction:

Improvephysical activity intensityVSAvoidarterial oxygen saturation

Core Design Contradiction:

SpeedVSQuantity of substance

Solution Approach 1:

The patent applies preliminary action by administering the kaempferol analog composition before intense physical activity. The compound pre-prepares the body's oxygen metabolism system, enabling improved oxygen consumption efficiency to be established before the hypoxic stress of intense exercise occurs, thereby maintaining better oxygen saturation levels during activity.

Inventive Principle:

Principle #10Preliminary action

3Reliability

If aging occurs, then oxygen status decreases from 97% to 93%, but no effective intervention exists

Engineering Contradiction:

Improveoxygen status maintenanceVSAvoidlong-term oxygen consumption efficiency

Core Design Contradiction:

ReliabilityVSDuration of action of moving object

Solution Approach 1:

The patent implements continuity of useful action through chronic administration of the kaempferol analog composition. The compound continuously enhances mitochondrial function and oxygen metabolism over time, counteracting the progressive decline in oxygen status associated with aging. This sustained intervention maintains oxygen consumption efficiency across long durations and prevents age-related deterioration.

Inventive Principle:

Principle #20Continuity of useful action

Data Source

PatentUS20240325348A1Kaempferol analog-containing composition

Publication Date: 2024.10.03 OTSUKA PHARM CO LTD

AI summary

The present application provides a method for improvement in physical activity efficiency, a method for reducing fatigue, and a method for improving dynamic/kinetic visual acuity, comprising administering a composition comprising a kaempferol analog to a subject in need thereof.