Engineered Kappa Peptide Variants for Selective Pest Control
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Solution Overview
Problem
There is a need for alternative, environmentally friendly pesticidal agents to protect economically important crops from destructive insects that pose threats to human health and food security.
Innovation Solution
Development of engineered, non-naturally occurring Kappa Peptide Variants (KPVs) with specific amino acid sequences and their agriculturally acceptable salts, which exhibit pesticidal activity against various pests, including engineered variants with specific amino acid substitutions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional chemical pesticides are used to control insect pests, then pest control effectiveness is achieved, but environmental pollution and harm to non-target organisms occur
Solution Approach 1:
The patent modifies the amino acid sequence parameters of the Kappa peptide by introducing specific substitutions (e.g., at positions 3, 14, 24, 28, 31) to enhance pesticidal activity and selectivity. These parameter changes in the peptide structure enable more effective pest control while reducing environmental harm compared to traditional chemical pesticides
Solution Approach 2:
The invention creates a composite biological agent by combining the engineered Kappa peptide sequence with natural delivery mechanisms and expressing it in host organisms. This composite approach replaces synthetic chemical pesticides with a biologically-based solution that maintains effectiveness while improving environmental compatibility
2Reliability
If traditional chemical pesticides are used to control insect pests, then pest control effectiveness is achieved, but harm to beneficial insects and non-target organisms occurs
Solution Approach 1:
The engineered Kappa peptide exhibits local quality through its specific amino acid substitutions that confer insect-specific activity. The peptide structure is designed to target particular pest insect populations while leaving beneficial insects unharmed, achieving selective pest control that protects non-target organisms
3Object-generated harmful factors
If natural pest control methods are used, then environmental safety is maintained, but pest control effectiveness is insufficient
Solution Approach 1:
The patent applies parameter changes to the natural Kappa peptide sequence by introducing specific amino acid substitutions that enhance its pesticidal activity. This allows the naturally-derived peptide to achieve sufficient effectiveness for practical pest control while maintaining environmental safety and avoiding the harms of synthetic chemicals
Data Source
AI summary
An engineered, non-naturally occurring pesticidal Kappa Peptide Variant (KPV), or an agriculturally acceptable salt thereof, comprising, consisting essentially of, or consists of, an amino sequence that is at least 90%, 95%, 96%, 97%, 97%, 98%, 99%, or 100% identical to a sequence set forth in any one of SEQ ID NOs: 2-7, 10-13, 16-19, 23, 25, 30-31, 35, 39-40, 45-46, 48, 50, 54-57, 60, 66, 68, 70-71, 73-74, 76-79, 85, 102, 110, 114, 124, 126, 140, 146-147, 149, 151-152, 157-158, 160-162, 164, 167-168, 170, 173, 176, 178, 180, 183-186, 189, 191-192, 195, 199, 204-206, 209-212, 215-218, 220-233, 235-240, 243-260, 263-265, 269-270, 274-280, 282-292, 294, 296-297, 299-300, 302-306, 308, 312-313, 315-323, 325, 327-329, 331-332, 334, 343-344, 346-348, 350, 354-355, or 35, is described, along with methods of making and using the same. The present disclosure is also related to and describes novel pesticidal compositions, formulations, and methods of using the same, that are useful for the control of plant pests.