Keto-Analogue Dietary Product for Lower-Nitrogen Hypoproteic Diets
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing dietary products for patients with chronic kidney disease, hepatic insufficiency, and urea cycle disorders suffer from high nitrogen content, poor taste, and require frequent administration, leading to low patient compliance and fluid restriction challenges.
Innovation Solution
A dietary product comprising essential amino acids, keto and hydroxy analogues, and pharmaceutically acceptable excipients like medium chain glycerine triesters, Arabic gum, and starch sodium octenyl succinate, which improves organoleptic features and reduces liquid intake, allowing twice-daily administration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If dietary products use traditional excipients, then manufacturing is simple, but organoleptic features are poor and patient compliance is low
Solution Approach 1:
The patent applies composite materials by combining three specific excipients (medium chain glycerine triesters, Arabic gum, and starch sodium octenyl succinate) to create a synergistic formulation. This composite excipient system improves organoleptic features including taste, odor, and texture while maintaining ease of manufacture through straightforward mixing processes.
2Reliability
If dietary products require frequent administration, then therapeutic effect is maintained, but patient compliance decreases
Solution Approach 1:
The patent changes the parameters of the dietary product formulation by incorporating specific excipients that enhance stability and bioavailability. This allows the product to maintain therapeutic effectiveness with less frequent administration (twice daily), thereby improving patient compliance without compromising therapeutic reliability.
3Ease of operation
If dietary products require high liquid intake, then dissolution is improved, but fluid restriction challenges arise in kidney disease patients
Solution Approach 1:
The patent changes the physical parameters of the excipient system to enable dissolution in smaller volumes of liquid. The medium chain glycerine triesters and modified starch create a formulation that dissolves effectively in reduced fluid volumes, addressing the needs of kidney disease patients who require fluid restriction.
4Quantity of substance
If dietary products have high nitrogen content, then protein needs are met, but uremic symptoms worsen in kidney disease patients
Solution Approach 1:
The patent applies local quality by providing essential amino acids (high biological value) in specific quantities that meet protein needs without excessive total nitrogen. The formulation targets the specific nutritional requirements of kidney disease patients by optimizing the amino acid profile rather than simply reducing all protein content.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The product achieves a lower nitrogen content, improves uremic symptoms, normalizes creatinine levels, and enhances patient compliance by reducing liquid intake and improving taste, while supporting low-protein diets.
Implementation Method 1
Keto- and hydroxy analogues are precursor compounds of amino acids, which are converted into the amino acids by a transamination reaction
Implementation Method 2
In the case of hydroxy analogues, an enzymatic oxidation reaction is carried out prior to the subsequent transamination reaction
Data Source
AI summary
It refers to a dietary product for hypoproteic diet suitable for supplementing the diet in patients suffering from chronic kidney disease, hepatic insufficiency and urea cycle disorders. It also refers to the use of the dietary product as supplement of the diet of said patients. The dietary product comprises amino acids, amino acid analogues, and pharmaceutically acceptable excipients.