Ketone Body Composition for ATP Biosynthesis
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Solution Overview
Problem
Existing athletic performance enhancement beverages face logistical challenges during extended exercises, particularly in remote areas, as they require large carbohydrate intake, which can lead to gastrointestinal distress and inefficient energy delivery due to high osmolality and timing issues, and creatine supplementation can inhibit ATP generation with potential toxicity.
Innovation Solution
A composition containing niacin, riboflavin, thiamine, pyruvate, ubiquinone, and lipoic acid, optionally with excipients like sodium, calcium, and potassium, designed to enhance ATP biosynthesis and oxidation of metabolic fuels, avoiding creatine to prevent ATP inhibition and toxicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Use of energy by moving object
If large amounts of carbohydrate-containing beverages are ingested during extended exercise, then energy supply for ATP production is improved, but gastrointestinal distress occurs and fluid balance is disrupted due to high osmolality
Solution Approach 1:
The patent changes the chemical parameters of the energy substrate by using ketone bodies (acetoacetate and beta-hydroxybutyrate) instead of carbohydrates. This fundamental parameter change allows energy delivery without the gastrointestinal distress associated with high-carbohydrate beverages, as ketone bodies can be metabolized directly by muscles without requiring extensive digestion and absorption processes that stress the gastrointestinal system during exercise
2Productivity
If carbohydrate-containing beverages are ingested during exercise, then plasma glucose increases and ATP production is enhanced, but timing issues and logistical challenges arise during extended exercise in remote areas
Solution Approach 1:
The patent applies preliminary action by having athletes consume ketone body supplements before exercise begins. This allows the ketone bodies to be absorbed and available in the bloodstream prior to exercise onset, eliminating the need for timing carbohydrate intake precisely during exercise. The ketone bodies are already prepared and available for immediate metabolism when energy is needed, solving the timing and logistical challenges of extended exercise in remote areas
3Use of energy by moving object
If creatine is supplemented to enhance ATP generation, then energy availability is improved, but ATP generation is inhibited and toxicity occurs
Solution Approach 1:
The patent applies the taking out principle by removing creatine from the energy supplementation approach entirely. Instead of using creatine monophosphate or creatine phosphate as an energy source, the invention extracts only the essential components needed for ATP production through ketone body metabolism. This elimination of creatine avoids the harmful effects of ATP inhibition and toxicity while maintaining effective energy supply through alternative metabolic pathways
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively maintains ATP supply, improves energy efficiency, reduces fatigue, aids in weight loss, enhances glucose tolerance, and addresses various health issues such as hypertension and erectile dysfunction by synergistically increasing ATP production and metabolic efficiency.
Implementation Method 1
The active component is effective, when ingested by an animal, for increasing or maximizing the biosynthesis potential of ATP within the animal and also for increasing the oxidation of several metabolic fuels including carbohydrates and lipids within the animal
Implementation Method 2
increasing the oxidation of several metabolic fuels including carbohydrates and lipids
Data Source
AI summary
A composition including a plurality of active ingredients. A first active ingredient of the active ingredients is pyruvate. For each other active ingredient, an amount of that active ingredient is proportionally less than an amount of the first active ingredient. The composition can affect ATP and Krebs efficiency when ingested by an animal.