Ketone Body Composition with NAD Modulator and Methyl Donor
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current exogenous ketone body supplements lack an NAD modulator to facilitate conversion to acetoacetate and often deplete methyl donors, leading to poor tolerability and side effects, making it difficult to achieve and maintain ketosis without restrictive diets.
Innovation Solution
A composition combining an exogenous ketone body, an exogenous NAD modulator, and a methyl donor, such as esters of (R)-3-hydroxybutyrate with nicotinamide riboside or derivatives, and vitamin B12, folate, to elevate ketone bodies and NAD levels while preventing methyl donor depletion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If exogenous ketone body supplements are administered, then ketone body levels are elevated, but methyl donor depletion occurs leading to side effects
Solution Approach 1:
The patent applies preliminary anti-action by pre-supplementing methyl donors (vitamin B12, folate, choline, betaine) in the composition before methyl donor depletion can occur. This preventive approach counteracts the anticipated harmful effect of methyl donor depletion that results from increased NAD modulator activity, thereby allowing sustained elevation of ketone body levels without experiencing side effects.
Solution Approach 2:
The patent employs composite materials by formulating a multi-component composition that integrates exogenous ketone bodies, NAD modulators, and methyl donors into a single synergistic formulation. This composite approach ensures that all necessary components are delivered together, allowing the system to simultaneously elevate ketone bodies while preventing methyl donor depletion through the included methyl donor supplements.
2Productivity
If NAD modulator is administered to facilitate ketone body conversion, then acetoacetate production increases, but methyl donor depletion occurs
Solution Approach 1:
The patent applies preliminary anti-action by including methyl donors in the composition before depletion occurs. The methyl donors (vitamin B12, folate, choline, betaine) are pre-positioned in the formulation to counteract the methyl donor consumption that inevitably results from enhanced NAD modulator activity and increased acetoacetate production, thereby maintaining both high conversion rates and adequate methyl donor levels.
Solution Approach 2:
The patent uses methyl donors as intermediary substances that mediate between NAD modulator activity and cellular methylation processes. By including these intermediaries (vitamin B12, folate, choline, betaine) in the composition, the system facilitates smooth metabolic transitions and prevents the harmful effects of methyl donor depletion that would otherwise result from increased acetoacetate production.
3Quantity of substance
If restrictive ketogenic diet is followed to achieve ketosis, then ketone body levels are elevated, but dietary sustainability becomes difficult
Solution Approach 1:
The patent applies the taking out principle by extracting the essential active components needed for ketosis (exogenous ketone bodies and NAD modulators) from the complex restrictive ketogenic diet regimen. This isolation of key active ingredients into a supplement formulation eliminates the need to follow stringent dietary restrictions while still achieving the desired elevation of ketone body levels, thereby dramatically improving ease of operation and dietary sustainability.
Solution Approach 2:
The patent uses exogenous ketone bodies and NAD modulators as intermediary substances that mediate the transition to ketosis without requiring adherence to a restrictive diet. These intermediaries directly elevate ketone body levels and enhance metabolic conversion pathways, serving as a shortcut that bypasses the need for dietary manipulation while achieving the same physiological state.
4Device complexity
If exogenous ketone body supplement lacks NAD modulator, then supplement structure is simpler, but conversion to acetoacetate is inefficient
Solution Approach 1:
The patent applies merging by combining multiple functional components (exogenous ketone bodies, NAD modulators, and methyl donors) into a single integrated supplement formulation. This combination ensures that all necessary elements for efficient ketone body metabolism are present together, enabling effective conversion to acetoacetate while maintaining a unified, user-friendly product structure that does not compromise on functionality.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively raises ketone bodies and NAD levels, improving energy metabolism, reducing side effects, and treating various clinical conditions, including metabolic disorders, neurocognitive impairments, and enhancing performance without the need for strict dietary ketosis.
Implementation Method 1
Ketosis is facilitated by nicotinamide adenine dinucleotide (NAD) modulator, which facilitates the conversion of other ketone bodies (e.g., BHB) to acetoacetate
Implementation Method 2
NR raises blood and tissue NAD levels far above that of other B vitamin analogues
Data Source
AI summary
The present invention provides a composition comprising a mixture of an exogenous ketone body, an exogenous NAD modulator and a methyl donor. Typically, exogenous NAD modulator is an exogenous nicotinamide adenine dinucleotide (NAD) precursor. The present invention also provides a method of using such a composition for treating various clinical conditions, including metabolic disorders and neurocognitive impairments. The compositions of the invention can also be used to improve human performance in various competitive or environmental conditions.