Ketorolac and B-Complex Synergistic Pharmaceutical Composition
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current pain management therapies, particularly for moderate to severe pain and neuralgias, face challenges due to the side effects of opioids and instability issues with non-steroidal anti-inflammatory drugs (NSAIDs) when combined with other substances, leading to inadequate therapeutic efficacy and increased adverse effects.
Innovation Solution
A pharmaceutical composition combining ketorolac salts with B-complex vitamins, using smaller doses of ketorolac and B-complex, and employing specific buffer solutions to maintain stability and pH levels, allowing for a synergistic effect in pain management with reduced adverse effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If opioids are used for pain management, then analgesic effect is improved, but side effects such as respiratory depression, constipation, and tolerance increase
Solution Approach 1:
The invention segments the pain management approach by combining two different mechanisms: NSAID (ketorolac) for inflammatory pain control and Vitamin B-complex for neuralgia and nerve pain relief. This segmentation allows targeting different pain pathways without relying on opioids, thereby reducing opioid-related side effects while maintaining comprehensive analgesic coverage
Solution Approach 2:
The invention creates a composite pharmaceutical formulation combining ketorolac (NSAID) with Vitamin B-complex. This composite approach leverages the anti-inflammatory properties of ketorolac and the neuroprotective/analgesic properties of B-vitamins to achieve synergistic pain relief without opioid involvement, thus improving reliability while reducing harmful effects
2Reliability
If NSAIDs are combined with other substances, then therapeutic efficacy is improved, but stability decreases
Solution Approach 1:
The invention uses Vitamin B-complex as an intermediary substance that not only provides therapeutic benefit for neuralgia but also acts as a stabilizing agent in the formulation. The B-vitamins serve as a bridge between the NSAID component and the overall formulation stability, allowing enhanced therapeutic efficacy while maintaining compositional stability through their buffering and protective effects
3Duration of action of moving object
If repeated parenteral administration of diclofenac and B-complex is performed, then pain relief is maintained, but tissue necrosis risk increases
Solution Approach 1:
The invention changes the chemical parameters of the formulation by using ketorolac instead of diclofenac, altering the pH profile and chemical composition to reduce tissue reactivity. This parameter change allows repeated parenteral administration to be performed safely without causing tissue necrosis, while maintaining effective pain relief duration through the synergistic ketorolac-B-complex combination
Data Source
Figure 1~2
Figure 3~4
Figure 5
AI summary
This invention refers to the pharmaceutical combinations of Ketorolac salts and B-complex; to the methods used to make said combinations; and particularly, to ketorolac and B-complex synergic combinations useful in the treatment of patients that suffer from moderate to severe pain and neuralgias in different body sites.