Antioxidant Composition for Kidney Disease Prevention
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Solution Overview
Problem
Despite years of research, kidney disease and poor renal function remain a significant health issue, with existing antioxidant treatments being inconclusive in effectiveness for prevention and treatment.
Innovation Solution
A composition containing at least 500 ppm vitamin E, 100 ppm L-carnitine, 25 ppm α-lipoic acid, and 1% by weight of dried spinach, carrot, or citrus pulp, administered in food compositions or kits, which also include renal drugs, to reduce oxidative stress and improve kidney function.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If antioxidant supplements are administered to treat kidney disease, then oxidative stress is reduced, but the effectiveness is inconclusive and may have pro-oxidant properties
Solution Approach 1:
The patent applies composite materials by combining multiple antioxidants (vitamin E, vitamin C, alpha-lipoic acid) with specific plant extracts (spinach, carrot, citrus pulp, grape pomace) in defined proportions. This composite approach creates a synergistic formulation where each component contributes to antioxidant activity while potentially mitigating the pro-oxidant effects of individual supplements, thereby improving reliability and reducing harmful effects.
Solution Approach 2:
The patent specifies precise concentration parameters for each antioxidant component (e.g., vitamin E at 500-2000 IU/kg, vitamin C at 100-500 mg/kg) to optimize therapeutic effect while minimizing pro-oxidant properties. By carefully controlling these parameters, the formulation achieves reliable kidney protection without the adverse effects seen in uncontrolled antioxidant supplementation.
2Reliability
If a combination of multiple antioxidants is used, then protective effect against oxidative damage is enhanced, but the complexity of the composition increases
Solution Approach 1:
The patent merges multiple antioxidant agents into a single integrated formulation, combining synthetic antioxidants (vitamin E, vitamin C, alpha-lipoic acid) with natural plant extracts (spinach, carrot, citrus pulp, grape pomace). This consolidation provides comprehensive oxidative protection while simplifying administration compared to multiple separate supplements, effectively managing composition complexity.
3Duration of action of stationary object
If antioxidant treatment is applied to senior animals, then kidney function deterioration is slowed, but the cost of treatment increases
Solution Approach 1:
The patent incorporates relatively inexpensive plant-based ingredients (spinach, carrot, citrus pulp, grape pomace) that can be sourced economically, making the treatment cost-effective for long-term use in senior animals. These affordable natural antioxidants provide sustained kidney protection without the high costs associated with more expensive pharmaceutical interventions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively prevents and treats kidney disease by reducing oxidative stress, improving kidney function, and decreasing morbidity and mortality, particularly in senior animals.
Implementation Method 1
the production of active oxygen species or free radicals during aerobic respiration results in oxidative damage that hastens aging and death in animals
Implementation Method 2
Free radicals, often produced in the mitochondria, where aerobic respiration occurs, damage mitochondrial DNA, proteins, and lipids
Implementation Method 3
The role of reactive oxygen metabolites in glomerular disease
Data Source
AI summary
The invention provides compositions for preventing or treating kidney disease and improving kidney function comprising at least two ingredients selected from the group consisting of antioxidants and mitochondrial cofactors in amounts sufficient for preventing or treating kidney disease or for improving kidney function and methods for preventing and treating kidney disease or improving kidney function comprising administering such compositions to an animal susceptible to or suffering from kidney disease or impaired kidney function. In a preferred embodiment, the composition is admixed with one or more food ingredients to produce a food composition useful for preventing or treating kidney disease and improving kidney function, particularly in senior animals.