Antioxidant Composition for Kidney Disease Treatment
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Solution Overview
Problem
Kidney disease remains a significant health issue despite existing studies, with inconclusive evidence on the effectiveness of antioxidant treatments, and there is a need for new methods and compositions to prevent and treat the condition.
Innovation Solution
A composition comprising vitamin E, vitamin C, and a carotenoid, specifically beta-carotene, is administered to patients to reduce oxidative stress and alter kidney function, thereby preventing or treating kidney disease, often in conjunction with food compositions and renal drugs.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If antioxidant supplements are administered to treat kidney disease, then oxidative stress is reduced, but the effectiveness remains inconclusive and may have pro-oxidant properties
Solution Approach 1:
The patent combines three different antioxidants (vitamin E, vitamin C, and carotenoids) into a single composition. This synergistic combination addresses the inconclusive results of individual antioxidant treatments by utilizing multiple mechanisms simultaneously - vitamin E provides lipid-soluble antioxidant protection, vitamin C provides water-soluble antioxidant protection, and carotenoids provide additional antioxidant and anti-inflammatory effects, thereby improving treatment reliability while reducing oxidative stress
Solution Approach 2:
The invention creates a composite antioxidant composition containing multiple distinct antioxidant substances with different chemical properties and mechanisms of action. This composite approach allows the formulation to address the limitations of single-antioxidant treatments by providing both immediate antioxidant protection and long-term protective effects through the complementary actions of vitamin E, vitamin C, and carotenoids
2Ease of operation
If conventional kidney disease treatments are used, then some symptoms are managed, but morbidity and mortality remain high
Solution Approach 1:
The patent emphasizes prevention through antioxidant supplementation before kidney disease fully develops or progresses. By administering antioxidant compositions early in the disease process or even preventively to at-risk populations, the treatment aims to reduce oxidative damage before it causes irreversible kidney damage, thereby reducing both morbidity and mortality while maintaining ease of operation through simple oral administration
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition effectively decreases oxidative stress and improves kidney function, as demonstrated by reduced serum urea nitrogen levels and decreased DNA damage in cats with renal insufficiency, indicating its potential in preventing and treating kidney disease.
Implementation Method 1
the production of active oxygen species or free radicals during aerobic respiration results in oxidative damage
Implementation Method 2
antioxidant treatment is beneficial to those with kidney disease
Data Source
AI summary
The invention provides compositions for preventing or treating kidney disease comprising vitamin E, vitamin C, and a carotenoid and methods for preventing and treating kidney disease comprising administering such compositions to an animal susceptible to or suffering from kidney disease. In a preferred embodiment, the composition is admixed with one or more food ingredients to produce a food composition useful for preventing or treating kidney disease.