Loco-renal perfusion via closed circuit isolation
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Solution Overview
Problem
Current gene therapy and cell therapy techniques for renal conditions face challenges in drug delivery, including vector efficiency, dose specificity, safety, and invasiveness, particularly in targeting the kidneys effectively while minimizing systemic exposure and adverse immune responses.
Innovation Solution
A method and system for perfusing a drug through a closed circuit isolated from systemic circulation, using a perfusion catheter in the renal artery and a recovery catheter in the renal vein, with a membrane oxygenation device, to achieve localized delivery of therapeutic agents to the kidneys, reducing exposure and allowing for nephrotoxic drug administration while minimizing kidney exposure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If gene therapy and cell therapy techniques are used to treat renal conditions, then treatment efficacy is improved, but delivery specificity and safety are compromised due to systemic exposure
Solution Approach 1:
The invention divides the drug delivery system into two separate catheters: a perfusion catheter for delivering therapeutic agents into the renal artery and a recovery catheter for draining blood from the renal vein. This segmentation enables localized renal perfusion while isolating the treatment from systemic circulation, thereby maintaining treatment efficacy while reducing harmful systemic exposure
Solution Approach 2:
The closed-loop perfusion system provides localized drug delivery specifically to the kidney by establishing a separate circulation pathway. The perfusate containing therapeutic agents is circulated only through the renal vasculature, creating a localized treatment environment that spares other organs from exposure to potentially toxic drugs
2Reliability
If higher drug doses are administered to achieve therapeutic effect, then treatment efficacy is improved, but adverse immune responses and toxicity increase
Solution Approach 1:
The invention extracts the kidney from the systemic circulation by creating a separate closed-loop perfusion circuit. This allows administration of higher drug doses to the kidney without exposing the rest of the body to toxic levels, thereby achieving therapeutic efficacy while minimizing adverse immune responses and systemic toxicity
Solution Approach 2:
The closed-loop perfusion system acts as an intermediary between the drug and the kidney, allowing controlled delivery of high-dose therapeutic agents. The perfusate serves as a mediator that carries drugs directly to renal tissue while preventing systemic distribution, thus enabling high-dose treatment without proportional increase in adverse effects
3Ease of operation
If minimally invasive delivery is used to reduce patient trauma, then ease of operation is improved, but delivery precision and homogeneity are compromised
Solution Approach 1:
The invention merges the benefits of minimally invasive catheter-based delivery with the precision of controlled perfusion by combining the perfusion catheter and recovery catheter into a coordinated closed-loop system. This integration maintains the minimally invasive nature of the procedure while achieving homogeneous drug distribution throughout the kidney through controlled circulatory flow
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables targeted, minimally invasive delivery of therapeutic agents to the kidneys with reduced systemic leakage and adverse responses, allowing for higher drug doses and effective treatment of renal conditions like autosomal dominant polycystic kidney disease and nephronophthisis without systemic toxicity.
Implementation Method 1
positioning a recovery catheter in the renal vein of the kidney such that the perfusion catheter and the recovery catheter together with a membrane oxygenation device form a closed perfusion circuit through the kidney
Data Source
AI summary
Disclosed is a method for treating a renal condition by loco-regional perfusion of one or both of a patient's kidneys (1810). A closed circuit may be formed with a perfusion catheter (1822) positioned in the renal artery of the kidney, a recovery catheter (1824) positioned in the renal vein of the kidney, and an external membrane oxygenator (1820) disposed therebetween. A perfusate containing, for example, a drug may be circulated through the closed circuit while isolating the closed circuit from the patient's systemic circulation.