Killed Enterococcus faecalis EF-2001 Inhibits Oxidative Stress Muscle Damage

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Solution Overview

Problem

Current treatments for muscle weakness and atrophy, such as sarcopenia and disuse atrophy, lack effective and cytotoxicity-free solutions, particularly in addressing oxidative stress-induced muscle cell damage.

Innovation Solution

A pharmaceutical, food, and food additive composition containing Enterococcus faecalis EF-2001, or its culture solution or killed body, which inhibits muscle cell damage by oxidative stress, administered in a pharmaceutically effective amount to prevent and treat muscle weakness and atrophy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional treatments for muscle weakness and atrophy are used, then some therapeutic effect may be achieved, but cytotoxicity and side effects occur

Engineering Contradiction:

Improvetherapeutic effectVSAvoidcytotoxicity

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses killed E. faecalis cells instead of live bacteria, creating a disposable, non-replicating therapeutic agent that eliminates concerns about bacterial overgrowth or infection while maintaining therapeutic benefits through cell wall components and metabolites

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

Solution Approach 2:

The patent converts the potentially harmful oxidative stress that causes muscle cell damage into a beneficial therapeutic mechanism by using E. faecalis components to induce protective autophagy and mitigate oxidative damage, transforming the harmful pathway into a protective response

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

2Productivity

If oxidative stress is present in muscle cells, then metabolic processes continue, but muscle cell damage and apoptosis occur

Engineering Contradiction:

Improvemetabolic activityVSAvoidoxidative stress damage

Core Design Contradiction:

ProductivityVSObject-affected harmful factors

Solution Approach 1:

The patent administers E. faecalis components before oxidative stress becomes severe, inducing protective autophagy and upregulating antioxidant defenses in advance to cushion against upcoming oxidative damage and prevent muscle cell apoptosis

Inventive Principle:

Principle #11Beforehand cushioning (Prior cushioning)

Solution Approach 2:

The patent uses E. faecalis cell wall components and metabolites as intermediary substances that mediate between oxidative stress and muscle cell protection, triggering protective signaling pathways and autophagy without directly causing damage

Inventive Principle:

Principle #24Intermediary (Mediator)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

Killed Enterococcus faecalis EF-2001 exhibits no cytotoxicity and effectively inhibits muscle cell damage and apoptosis induced by oxidative stress, demonstrating a remarkable treatment effect for muscle loss, weakness, and atrophy, making it suitable for compositions and additives.

Implementation Method 1

inhibiting the damage to muscle cells induced by oxidative stress

Methodology Applied

Scientific EffectOxidative stress: Oxidation

Data Source

PatentUS11679134B2Pharmaceutical composition, food composition and food additive for preventing, alleviating or treating muscle loss, weakness and atrophy, containing, as active ingredient, <i>Enterococcus faecalis</i>, culture liquid thereof or dead cells thereof

Publication Date: 2023.06.20 KOREA BERM CO LTD

AI summary

The present invention relates to a pharmaceutical composition, a food composition, and a food additive for the prevention and treatment or improvement of muscle loss, muscle weakness, and muscle atrophy, which contain Enterococcus faecalis, particularly Enterococcus faecalis EF-2001 among others, a culture solution thereof, or a killed body thereof as an active ingredient. Killed Enterococcus faecalis EF-2001 of the present invention exhibits a remarkable treatment effect for muscle loss, muscle weakness, and muscle atrophy by inhibiting the damage to muscle cells induced by oxidative stress, and thus killed lactic acid bacterium Enterococcus faecalis EF-2001 of the present invention or a culture solution thereof can be usefully used as an active ingredient in a pharmaceutical composition, a food composition, and a food additive for prevention of muscle atrophy and sarcopenia.