Kirigami Grippers for Flexible Container Mixing

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Solution Overview

Problem

Existing fluidic mixing systems face challenges such as limited parallelization and throughput, high shear stresses induced by rigid actuators, and the need for costly and bulky equipment with large footprints.

Innovation Solution

The use of one or more grippers to deform a flexible container, inducing fluid flow and mixing within the container, while allowing for a smaller footprint, parallel operation, and reduced shear stress.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Power

If rigid actuators are used to mix fluid, then mixing power is improved, but shear stress on biological materials increases

Engineering Contradiction:
Improvemixing powerVSAvoidshear stress
Core Design Contradiction:
PowerVSObject-affected harmful factors

Solution Approach 1:

The patent employs flexible containers made of elastomeric materials that can be cyclically deformed by grippers. This flexible container approach replaces rigid mixing actuators, allowing the container walls to flex and generate gentle fluid flow patterns that mix effectively without imposing high shear stresses on sensitive biological materials.

Inventive Principle:
Principle #30Flexible shells and thin films

2Power

If conventional fluid mixers are used, then mixing capability is improved, but device footprint and cost increase

Engineering Contradiction:
Improvemixing capabilityVSAvoiddevice footprint
Core Design Contradiction:
PowerVSArea of stationary object

Solution Approach 1:

The mixing system is segmented into discrete functional components: support structures, flexible containers, and gripper actuators. This modular segmentation allows for compact integration and reduced overall device footprint while maintaining effective mixing capability through the coordinated action of these simplified components.

Inventive Principle:
Principle #1Segmentation

Solution Approach 2:

The gripper actuators are designed to interface directly with the flexible container from the outside, with the container nested within the gripper's gripping area. This nested configuration eliminates the need for large external mixing chambers and reduces the device footprint significantly.

Inventive Principle:
Principle #7Nested doll (Nesting)

3Ease of operation

If manual mixing processes are used, then simplicity is maintained, but throughput and efficiency decrease

Engineering Contradiction:
ImprovesimplicityVSAvoidthroughput
Core Design Contradiction:
Ease of operationVSProductivity

Solution Approach 1:

The system enables automated cyclic deformation of the flexible container through programmable gripper actuators. The container itself serves as the mixing vessel and responds autonomously to the deformation cycles, eliminating manual intervention while maintaining operational simplicity and enabling high-throughput automated processing.

Inventive Principle:
Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The described mixing systems achieve efficient and gentle fluid mixing with lower shear stresses, enabling improved viability of biological materials and a more compact, cost-effective design.

Implementation Method 1

the one or more grippers are configured to deform the flexible container to induce flow of the fluid within the flexible container

Methodology Applied
Scientific EffectFluid flow induction through compression: Compression

Implementation Method 2

deform the flexible container to induce flow of the fluid within the flexible container

Methodology Applied
Scientific EffectFluid mixing through induced flow: Convection

Data Source

PatentUS20250177935A1Kirigami mixers and methods of use
Publication Date: 2025.06.05 SARTORIUS STEDIM BIOTECH GMBH
  • US20250177935A1 patent drawing
  • US20250177935A1 patent drawing
  • US20250177935A1 patent drawing

AI summary

Kirigami mixing systems and related methods are generally described. In some embodiments, a mixing system includes one or more grippers configured to deform a portion of a flexible container containing fluid when undergoing axial deformation. The grippers may include features including slots, hinges, and spines to aid in the transition of the grippers between a closed and retracted configuration when the one or more grippers are deformed. The compression of the container subsequently result in fluid flow within the container which may mix or agitate the fluid. In some embodiments, the described grippers may be formed integrally with the flexible containers. In some embodiments, the mixing system may include a plurality of grippers arranged around the flexible container.