Klotho-Inducing Compounds for Oxidative Stress Protection in RPE Cells

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Solution Overview

Problem

Current treatments for age-related macular degeneration do not effectively address oxidative stress and the reduction of Klotho gene expression, which is associated with aging and related diseases.

Innovation Solution

Development of novel compounds represented by Formula 1 and their pharmaceutically acceptable salts, which enhance Klotho gene expression and provide protection against oxidative stress in retinal pigment epithelial cells.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If current treatments for age-related macular degeneration are used, then treatment is provided, but oxidative stress and reduced Klotho gene expression are not effectively addressed

Engineering Contradiction:

Improveeffectiveness of treatmentVSAvoidoxidative stress

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The compound converts the harmful effect of oxidative stress into a beneficial outcome by inducing Klotho gene expression, which then protects retinal pigment epithelial cells from oxidative damage. The Klotho protein acts as a protective mechanism that transforms the cell's vulnerability to oxidative stress into resistance through upregulated expression.

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Solution Approach 2:

The compound changes the expression level parameter of the Klotho gene, increasing it from a reduced state to an elevated state. This parameter change in gene expression directly addresses the underlying cause of macular degeneration associated with aging and oxidative stress.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If current treatments are used, then treatment is provided, but Klotho gene expression reduction is not addressed

Engineering Contradiction:

Improveeffectiveness of treatmentVSAvoidKlotho gene expression

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The compound performs preliminary action by inducing Klotho gene expression before oxidative stress can cause significant damage to retinal pigment epithelial cells. This preemptive upregulation of Klotho provides protective effects that prevent rather than merely treat the progression of macular degeneration.

Inventive Principle:

Principle #10Preliminary action

Data Source

PatentUS20250206707A1Novel compound inducing expression of Anti-aging gene klotho

Publication Date: 2025.06.26 KLOTHO SCI

AI summary

The present invention relates to novel compounds that induce the expression of the anti-aging gene klotho. The compounds according to the invention are not only effective in enhancing the expression of the Klotho gene, a gene associated with aging, but also have a protective effect against oxidative stress in retinal pigment epithelial cells (RPE), and are therefore useful as a pharmaceutical composition or as a health functional food composition for the prevention or treatment of macular degeneration.