Koji Mold Enzyme Composition for Dual Gut Flora Enhancement
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Solution Overview
Problem
Existing technologies have not effectively increased the numbers of both bacteria of genus Bifidobacterium and bacteria of genus Lactobacillus in the intestine to improve intestinal flora.
Innovation Solution
The use of a lipase derived from a koji mold, such as Aspergillus niger, and/or a cellulase, particularly from Aspergillus niger, to increase the numbers of both bacteria of genus Bifidobacterium and bacteria of genus Lactobacillus in the intestine.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional probiotics or prebiotics are administered, then beneficial bacteria become predominant to improve intestinal flora, but no single agent has been found that can simultaneously increase both Bifidobacterium and Lactobacillus numbers
Solution Approach 1:
The invention uses a composite enzyme preparation containing multiple types of enzymes (amylase, protease, lipase, cellulase, and/or pectinase) derived from Aspergillus niger. This composite enzyme system works synergistically to degrade various food components (starch, protein, fat, cellulose, pectin) into different types of fermentation substrates that support the growth of both Bifidobacterium and Lactobacillus species, thereby simultaneously increasing the numbers of both beneficial bacterial genera in the intestine.
2Quantity of substance
If enzyme blends are administered to improve intestinal flora, then lactobacilli numbers increase and harmful bacteria decrease, but the effect on Bifidobacterium is not sufficient and no agent has been found that can increase both Bifidobacterium and Lactobacillus
Solution Approach 1:
The invention utilizes Aspergillus niger, a commonly used koji mold in food fermentation, to produce the enzyme preparation. This organism is already well-established in industrial fermentation processes, making the enzyme preparation easy to manufacture using existing infrastructure and expertise. The Aspergillus niger produces a broad spectrum of enzymes that naturally occur in the organism, eliminating the need for complex multi-organism fermentation systems or sophisticated manufacturing processes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The lipase and cellulase enhance the formation of a beneficial bacteria-dominated flora, promoting a healthy intestinal environment and potentially preventing or treating diseases associated with an unhealthy intestinal environment.
Implementation Method 1
a lipase derived from a koji mold and/or a cellulase, which can increase the numbers of bacteria of genus Bifidobacterium and bacteria of genus Lactobacillus in the intestine
Data Source
AI summary
An object of the present invention is to provide an agent for improving intestinal flora that can increase the numbers of bacteria of genus Bifidobacterium and bacteria of genus Lactobacillus in the intestine to improve the intestinal flora. (i) A lipase derived from a koji mold and/or (ii) a cellulase can increase the numbers of both bacteria of genus Bifidobacterium and bacteria of genus Lactobacillus in the intestine to exert an excellent effect of improving the intestinal flora.