Krill Oil and Astaxanthin Composition for Joint Pain Relief

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Solution Overview

Problem

Current treatments for osteoarthritis and rheumatoid arthritis, such as NSAIDs and hyaluronic acid injections, have limited effectiveness and are associated with side effects, prompting the need for alternative therapeutic approaches that can effectively alleviate joint pain and inflammation.

Innovation Solution

A therapeutic composition combining krill oil with astaxanthin and low molecular weight polymers of hyaluronic acid or sodium hyaluronate, optionally including additional active constituents like glucosamine sulfate, chondroitin sulfate, and cyclooxygenase inhibitors, administered in an oral dosage form to treat osteoarthritis and rheumatoid arthritis.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If NSAIDs are used to treat osteoarthritis and rheumatoid arthritis, then pain and inflammation are reduced, but side effects increase

Engineering Contradiction:

Improveeffectiveness in reducing pain and inflammationVSAvoidside effects

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent combines krill oil with astaxanthin and low molecular weight hyaluronic acid to create a composite therapeutic formulation. This composite approach leverages the anti-inflammatory properties of krill oil omega-3 fatty acids, the antioxidant and anti-inflammatory effects of astaxanthin, and the joint-protective benefits of hyaluronic acid, achieving enhanced therapeutic effectiveness while avoiding the harmful side effects associated with NSAID use

Inventive Principle:

Principle #40Composite materials

2Reliability

If hyaluronic acid injections are used to treat joint pain, then joint function is improved, but treatment complexity and invasiveness increase

Engineering Contradiction:

Improvejoint function improvementVSAvoidinjection procedure complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent replaces the mechanical injection procedure with an oral dosage form. By formulating the therapeutic composition as an oral supplement containing krill oil, astaxanthin, and low molecular weight hyaluronic acid, the treatment eliminates the need for invasive injections while maintaining the joint function improvement benefits through systemic absorption and delivery to affected tissues

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

3Reliability

If krill oil is used alone to treat arthritis, then anti-inflammatory effects are achieved, but synergistic therapeutic potential is not maximized

Engineering Contradiction:

Improveanti-inflammatory effectVSAvoidtherapeutic potency

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent merges krill oil with astaxanthin and low molecular weight hyaluronic acid in a single therapeutic formulation. This combination creates synergistic effects where the omega-3 fatty acids in krill oil reduce inflammation, astaxanthin provides antioxidant protection and anti-inflammatory benefits, and hyaluronic acid supports joint structure and function, collectively achieving greater therapeutic potency than any single component alone

Inventive Principle:

Principle #5Merging (Combining)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The composition significantly reduces inflammation, pain, and stiffness, as well as improves joint function, with astaxanthin demonstrating potent anti-inflammatory and antioxidant properties, and low molecular weight hyaluronic acid fragments promoting site repair and immune system modulation.

Implementation Method 1

astaxanthin demonstrating potent anti-inflammatory and antioxidant properties

Methodology Applied

Scientific EffectAnti-inflammatory effect:

Implementation Method 2

astaxanthin demonstrating potent anti-inflammatory and antioxidant properties

Methodology Applied

Scientific EffectAntioxidant effect: Oxidation

Implementation Method 3

low molecular weight hyaluronic acid fragments promoting site repair and immune system modulation

Methodology Applied

Scientific EffectTissue repair:

Implementation Method 4

low molecular weight hyaluronic acid fragments promoting site repair and immune system modulation

Methodology Applied

Scientific EffectImmune system modulation:

Implementation Method 5

the Neptune Krill Oil reduced CRP by 19.3% compared to an increase by 15.7% observed in the placebo group

Methodology Applied

Scientific EffectAnti-inflammatory effect:

Implementation Method 6

The '808 publication gives details regarding this krill oil as derived using those general steps identified above... in an attempt to decrease lipid profiles in patients with hyperlipidemia

Methodology Applied

Scientific EffectLipid metabolism:

Data Source

PatentUS8962924B2Composition and method to alleviate joint pain

Publication Date: 2015.02.24 US NUTRACEUTICALS LLC

AI summary

Beneficial and synergistic effects for alleviating joint pain and symptoms of osteoarthritis and/or rheumatoid arthritis have been found with krill oil and/or marine oil in combination with other active constituents, including astaxanthin and polymeric hyaluronic acid or sodium hyaluronate (hyaluronan) in an oral dosage form.