L-DOPA Biodegradable Adhesive Compositions for Internal Wound Closure
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Solution Overview
Problem
Current surgical closure methods, such as suturing and the use of staples or stents, are not always compatible with diverse procedures and can lead to complications like leak, fistula, or stone formation, necessitating a need for biocompatible adhesives suitable for internal biological applications.
Innovation Solution
Development of non-cytotoxic, biodegradable adhesive compositions comprising the reaction product of a linear dicarboxylic acid, a saturated triol, and an aromatic amino acid, specifically using sebacic acid, PEG400, glycerol, and L-DOPA, which are used in self-adhesive devices like biozipper and biotape for wound closure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If sutured surgical closure in multiple layers is used, then reliability of wound closure is improved, but device complexity and surgical time increase
Solution Approach 1:
The patent extracts the core function of wound closure from complex multi-layer suturing and concentrates it into a single adhesive composition. The adhesive layer containing the reaction product of linear dicarboxylic acid, saturated triol, and aromatic amino acid provides sufficient closure reliability without requiring multiple tissue layers or complex suture techniques.
Solution Approach 2:
The patent merges multiple functional requirements (adhesion, biocompatibility, biodegradability) into a single integrated adhesive composition. This combines the benefits of reliable closure with simplified application, eliminating the need for separate suturing steps and reducing overall procedural complexity.
2Reliability
If permanent staples or stents are used for tissue repair, then wound closure reliability is improved, but harmful factors increase due to stone formation or infection risk
Solution Approach 1:
The patent changes the material parameters from permanent (staples, stents) to biodegradable. The adhesive composition is designed to degrade after performing its closure function, eliminating the long-term presence of foreign materials that could serve as nidus for stone formation or infection. The biodegradation parameter is specifically optimized to maintain reliability during healing then safely dissolve.
Solution Approach 2:
The patent employs a disposable, biodegradable adhesive composition that performs its function temporarily during the critical healing period then naturally degrades. This replaces permanent implants with a transient solution that eliminates long-term complications while providing sufficient closure reliability when needed.
3Productivity
If rapidly applied closure methods are used, then productivity is improved, but adaptability to different procedures decreases
Solution Approach 1:
The adhesive composition is designed with universal applicability across diverse surgical procedures including genitourinary, gastrointestinal, and other tissue repairs. The formulation adapts to different tissue types and procedural requirements while maintaining rapid application characteristics, providing both speed and versatility.
Solution Approach 2:
The patent optimizes the adhesive parameters (viscosity, setting time, adhesion strength) to enable rapid application while maintaining flexibility for different procedural contexts. The reaction product composition allows quick bonding without requiring complex preparation or adjustment for different tissue types.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The adhesive compositions provide effective, biocompatible, and safe wound closure with improved adhesion properties, reducing complications and enhancing surgical outcomes.
Implementation Method 1
adhesive compositions comprising the reaction product of a linear dicarboxylic acid, a saturated triol, and an aromatic amino acid
Data Source
AI summary
The present invention relates to non-toxic, biodegradable adhesive compositions comprising the reaction product of a linear dicarboxylic acid, a saturated triol, and an aromatic amino acid. In certain embodiments, the adhesive compositions comprise the reaction product of sebacic acid terminated-poly(ethylene glycol), glycerin, and L-DOPA. The present invention also relates to methods of using the adhesive compositions for the closure of various wounds. Further, the present invention provides surgical closure devices comprising an adhesive composition.