L-Glufosinate Ammonium Crystallization via Gaseous Ammonia
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Solution Overview
Problem
Current methods for preparing L-glufosinate ammonium salt involve complex multistep processes that require hazardous chemicals and result in low yield and purity, often necessitating conversion from acid addition salts, which is inefficient and environmentally challenging.
Innovation Solution
A novel single-step process suspends an acid addition salt of L-glufosinate in an alcohol solvent, contacts it with gaseous ammonia for complete dissolution, and then subjects the solution to conditions that precipitate the crystalline L-glufosinate ammonium salt, achieving high purity and yield without residual acid addition salts or by-products.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If conventional multistep processes are used to convert acid addition salt to ammonium salt, then the conversion can be achieved, but the process complexity increases and yield decreases
Solution Approach 1:
The patent combines multiple separate conversion steps into a single reaction step by using a mixed solvent system (water and alcohol) that enables direct transformation of acid addition salt to ammonium salt without intermediate isolation or additional reagents, thereby simplifying the manufacturing process and improving yield
Solution Approach 2:
The patent changes the solvent parameters by introducing a mixed solvent system comprising water and alcohol in specific ratios, which modifies the reaction conditions to enable direct conversion and crystallization in one step, eliminating the need for complex multistep procedures
2Manufacturing precision
If conventional methods are used to prepare L-glufosinate ammonium salt, then the product can be obtained, but the purity is reduced due to presence of acid addition salt and by-products
Solution Approach 1:
The patent utilizes phase transition by controlling the crystallization process in the mixed solvent system, where the ammonium salt crystallizes in a specific phase that excludes acid addition salts and by-products, achieving high purity through selective crystallization rather than requiring additional purification steps
Solution Approach 2:
The patent creates a local environment in the mixed solvent system where the crystallization conditions are optimized specifically for the ammonium salt, allowing it to form pure crystals while impurities remain in the mother liquor, achieving high purity through localized control of crystallization parameters
3Productivity
If hazardous chemicals are used in the conversion process, then the reaction can proceed, but environmental harm increases
Solution Approach 1:
The patent replaces hazardous chemicals with benign, easily disposable substances such as water and common alcohols as solvents, which can be removed by simple evaporation or distillation without requiring specialized waste treatment, thereby maintaining reaction efficiency while eliminating environmental harm
Solution Approach 2:
The patent converts the potentially harmful acid addition salt into the desired ammonium salt directly through a benign chemical transformation using ammonia in a water-alcohol system, turning a waste product into the final product while avoiding the generation of harmful by-products
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This process produces L-glufosinate ammonium salt with high purity and yield, free from acid addition salts and by-products, and is suitable for agrochemical formulations, offering improved environmental and operational efficiency.
Implementation Method 1
contacting the suspension with gaseous ammonia until complete dissolution of compound expressed by Formula (II) to form a solution
Implementation Method 2
subjecting the solution to conditions sufficient to precipitate the compound expressed by Formula (I)
Implementation Method 3
precipitating the compound expressed by Formula (I)
Data Source
AI summary
The present disclosure relates to a novel crystalline form of L-glufosinate ammonium salt and a process for preparation thereof. The present disclosure also provides compositions comprising said form and a method for the control of undesired plant growth using said compositions.