L-Glufosinate Crystal Forms for Stable Low-Hygroscopic Herbicides
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Solution Overview
Problem
Existing crystal forms of L-glufosinate exhibit deficiencies in stability and hygroscopicity, affecting the preparation, storage, and herbicidal efficacy of herbicides.
Innovation Solution
Development of new crystal forms A, B, C, D, and E of L-glufosinate, characterized by specific X-ray powder diffraction patterns and thermal properties, including ammonium salt and zwitterionic forms, with improved stability and hygroscopicity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If existing crystal forms of L-glufosinate ammonium salt are used, then the herbicidal activity is achieved, but the stability and hygroscopicity are poor
Solution Approach 1:
The patent applies parameter changes by discovering and utilizing different crystal forms (polymorphs) of L-glufosinate ammonium salt. Each crystal form has distinct X-ray powder diffraction patterns and differential scanning calorimetry characteristics, representing different physical parameter states of the same chemical compound. This allows optimization of stability and hygroscopicity properties without changing the chemical identity of the herbicide.
Solution Approach 2:
The patent exploits phase transitions between different crystal forms of L-glufosinate ammonium salt. By controlling crystallization conditions (pH, temperature, solvent), the patent achieves transition between metastable and stable crystal forms, each with different hygroscopicity and stability characteristics. The metastable forms can be converted to stable forms under specific conditions, providing control over the material properties.
2Duration of action of stationary object
If existing crystal forms are used, then preparation is possible, but storage stability is insufficient
Solution Approach 1:
The patent utilizes parameter changes by identifying crystal forms with specific physical parameters (diffraction patterns, melting points, solubility) that correlate with improved storage stability and reduced hygroscopicity. The stable crystal form exhibits superior storage characteristics compared to metastable forms.
Solution Approach 2:
The patent applies preliminary action by establishing specific crystallization protocols (pH control, temperature management, solvent selection) that directly produce the desired stable crystal form with optimal storage properties. This preliminary structuring of the material prevents subsequent degradation and hygroscopicity issues during storage.
3Reliability
If new crystal forms are developed, then stability and herbicidal effect are improved, but the preparation process becomes more complex
Solution Approach 1:
The patent manages preparation complexity by systematically varying crystallization parameters (pH, temperature, solvent type) to access different crystal forms. Each parameter change directs the crystallization toward a specific polymorph with desired properties, providing a controllable pathway despite the increased complexity.
Solution Approach 2:
The patent uses solvents and pH buffers as intermediaries to control the crystallization process. These intermediary substances mediate between the chemical compound and the desired crystal form, enabling selective formation of stable or metastable forms through controlled interaction conditions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The new crystal forms exhibit excellent stability, hygroscopicity, and herbicidal efficacy, enhancing the preparation, separation, and storage of herbicides, with high solubility and effective weed control.
Implementation Method 1
an X-ray powder diffraction pattern with characteristic peaks at 2θ of 16.658°±0.2°, 18.139°±0.2°, 23.960°±0.2°, 25.458°±0.2°, and 28.380°±0.2°
Implementation Method 2
differential scanning calorimetry characteristics
Data Source
AI summary
The present disclosure is directed to a crystal of L-glufosinate and a preparation method and use thereof. The crystal of L-glufosinate includes five crystal forms, namely crystal form A, crystal form B, crystal form C, crystal form D and crystal form E. These crystal forms show excellent effects in stability, hygroscopicity, storage, etc., which are beneficial to the preparation, separation and storage of herbicides, and at the same time have good solubility and good pharmacokinetics, which is further beneficial to improve the level and speed of herbicides to control weeds.