L-Glutamine Particle Size Reduction for Skin Stability
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Solution Overview
Problem
Glutamine, a key amino acid for skin health and wrinkle reduction, is unstable in solution, limiting its use in topical formulations due to low stability and high concentration requirements, necessitating a stabilized form with extended shelf life for cosmetic and therapeutic applications.
Innovation Solution
A dermatological composition with L-glutamine or its pharmaceutically acceptable salts, featuring particles with a median volume size of less than 15 microns, combined with excipients like oleic acid, glycerin, and hyaluronic acid, to enhance stability, bioavailability, and dermatological activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If L-glutamine is formulated at high concentrations to compensate for low stability, then the dermatological activity is improved, but the shelf life is reduced
Solution Approach 1:
The patent applies parameter changes by reducing the particle size of L-glutamine from conventional sizes to less than 15 microns (preferably less than 10 microns). This size reduction fundamentally changes the physical parameters of the formulation, enabling high dermatological activity at lower concentrations while improving stability and extending shelf life through enhanced dissolution and absorption characteristics
2Ease of manufacture
If L-glutamine particles with median volume size of approximately 25 microns are used, then the formulation is simple to produce, but the stability is low and high concentrations are required
Solution Approach 1:
The patent changes the particle size parameter from conventional 25 microns to less than 15 microns (preferably less than 10 microns). This parameter modification improves stability without significantly complicating manufacturing, as the micronization process is a standard pharmaceutical technique that can be integrated into existing formulation workflows
3Ease of manufacture
If L-glutamine is used in conventional particle sizes, then the production cost is reasonable, but the dermatological action is insufficient and shelf life is extended
Solution Approach 1:
The patent modifies the particle size parameter to less than 15 microns, which enhances dermatological action through improved skin penetration and bioavailability. The cost increase from micronization is offset by the ability to use lower concentrations of the active ingredient, making the overall formulation cost-effective
Data Source
AI summary
This patent application relates to a dermatological composition intended for use by topical administration, as well as the non-therapeutic use of said composition to promote the densification and/or homogenization of the epidermis, reduce wrinkles, reduce stretch marks, plump and/or firm the skin.