L-Hyoscyamine Oral Formulations for Endoscopic Visualization
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Solution Overview
Problem
Endoscopic procedures outside the gastrointestinal tract face challenges with tissue motility, secretions, and spasms, which hinder visualization and imaging, especially in narrow tissues and cavities.
Innovation Solution
Rapidly disintegrating oral formulations of L-Hyoscyamine Sulfate tablets are administered to reduce tissue motility, dry secretions, and relax spasms, enhancing visibility and imaging during endoscopic procedures by inhibiting muscarinic acetylcholine receptors, thereby facilitating better access and imaging in non-gastrointestinal endoscopic procedures.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Illumination intensity
If endoscopy is performed in narrow tissues and cavities outside the gastrointestinal tract, then visualization and imaging can be achieved, but tissue motility, secretions, and spasms obstruct visualization and imaging
Solution Approach 1:
The patent applies preliminary action by administering L-hyoscyamine before the endoscopic procedure to pre-reduce tissue motility and dry secretions. This anticipatory treatment ensures that when the endoscope is inserted, the tissues are already in a more favorable state for visualization, preventing the harmful effects of motility and secretions from obstructing the procedure.
Solution Approach 2:
L-hyoscyamine serves as an intermediary substance that mediates between the endoscopic procedure and the problematic tissue responses. By blocking muscarinic acetylcholine receptors, it interrupts the pathway that leads to tissue motility and secretions, effectively acting as a mediator that allows the endoscope to visualize tissues without being obstructed by these harmful factors.
2Ease of operation
If rapidly disintegrating oral formulations of L-Hyoscyamine are administered, then tissue motility is reduced and secretions are dried, but the procedure requires additional pharmacological intervention
Solution Approach 1:
The patent replaces potential mechanical challenges (difficult endoscope advancement due to tissue motility) with a pharmacological solution (L-hyoscyamine administration). Instead of developing more complex mechanical endoscope designs to navigate motile tissues, the invention substitutes a drug that chemically reduces tissue motility, making the procedure easier to perform.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The use of L-Hyoscyamine Sulfate tablets improves endoscopic procedures by reducing tissue motility and secretions, allowing clearer visualization and imaging, particularly in narrow tissues and cavities, and extending the effectiveness of techniques like narrow band imaging and optical coherence tomography.
Implementation Method 1
The present invention pertains to single active pharmaceutical ingredient oral formulations of L-Hyoscyamine and not formulations containing atropine or D-Hyoscyamine. The pharmaceutical use of anticholinergic agents for the treatment of numerous medical conditions is well known in the prior art. The terms 'anticholinergic agent' or 'anticholinergics' refer to substances that oppose the action of the neurotransmitter acetylcholine.
Data Source
AI summary
Methods of performing non-gastrointestinal endoscopic procedures with concomitant dosing with rapidly disintegrating oral formulations of single active ingredient L-Hyoscyamine rapidly dissolving tablets.