L1 Polypeptide Coated Neural Probes for Chronic Recording
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Solution Overview
Problem
Current neural probes experience a decline in recording and stimulation performance over time due to detrimental tissue responses and impairment of neural function, leading to reduced quality and quantity of neural signals, especially in chronic implantations.
Innovation Solution
The development of neural probes with a parylene C insulating layer and an effective amount of L1 polypeptide or its functional fragment on the exterior surface, which enhances neuronal adhesion and reduces tissue reaction, allowing for prolonged effective neural recording and stimulation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Duration of action of stationary object
If neural probes are implanted for chronic recording, then the duration of action increases, but the recording quality and neural signal quantity deteriorate over time due to tissue response
Solution Approach 1:
The patent applies parameter changes by coating the neural probe surface with L1 polypeptide, which fundamentally alters the surface biochemical properties. This modification changes the interaction parameters between the probe and neural tissue, reducing detrimental tissue responses and maintaining stable recording quality over extended chronic implantation periods
Solution Approach 2:
The patent uses composite materials by combining the L1 polypeptide coating with the probe surface. This composite structure integrates the biological adhesion properties of L1 with the physical probe structure, creating a surface that promotes neuronal attachment while minimizing tissue reaction, thereby maintaining reliable recordings chronically
2Duration of action of stationary object
If neural probes are implanted for long-term clinical application, then the duration of action increases, but the quantity of neural signals deteriorates due to impairment of neural function
Solution Approach 1:
The L1 polypeptide coating changes the surface biochemical parameters to create a more neuron-friendly interface. This parameter modification reduces the impairment of neural function over time, allowing sustained detection of neural signals and maintaining signal quantity throughout long-term clinical applications
Solution Approach 2:
The L1 polypeptide acts as an intermediary substance between the probe surface and neural tissue. It mediates the interaction by promoting neuronal adhesion and reducing tissue reaction, thereby preserving the quantity of detectable neural signals during chronic implantation
3Reliability
If neural probes are coated with L1 polypeptide, then neuronal adhesion improves and tissue reaction reduces, but the device complexity increases due to additional coating layers
Solution Approach 1:
The patent applies local quality by coating only the surface of the neural probe with L1 polypeptide, leaving the rest of the device structure unchanged. This localized modification improves neuronal adhesion and reduces tissue reaction without requiring complex changes to the entire device architecture
Solution Approach 2:
The L1 polypeptide serves as a simple intermediary coating layer that provides the desired biological functionality. This single-layer approach achieves improved neuronal adhesion and reduced tissue reaction without the need for complex multi-layer structures or sophisticated device modifications
Data Source
AI summary
Disclosed herein are neural probes comprising an L1 polypeptide functional fragment thereof on the exterior surface of the probe, devices including such electrodes, and methods of their use. The disclosed embodiments are useful, for example, for in methods of recording and/or stimulating neural signals in a subject.