Lab Automation Camera Calibration via Sample Container

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Solution Overview

Problem

Existing laboratory automation systems face challenges in achieving reliable and cost-effective geometry and color calibration for sample containers, which is crucial for accurate processing and handling of laboratory samples.

Innovation Solution

A laboratory automation system equipped with a digital grey scale or color camera and an image processing device that uses a calibration element with known geometrical or color properties to determine the geometrical properties of sample containers and samples through digital image analysis, eliminating the need for prior calibration and reference data.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If traditional geometry and color calibration methods are used for sample containers, then measurement precision can be achieved, but device complexity and cost increase due to requiring prior calibration procedures and reference data

Engineering Contradiction:
Improvegeometry and color calibration precisionVSAvoidcalibration procedure complexity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system performs self-calibration by using the sample container itself as the calibration reference. The image processing device automatically determines geometrical properties and color characteristics of the container from captured images, eliminating the need for external calibration standards or manual calibration procedures. The container's own features (geometry, color, transparency) serve as the reference for calibration.

Inventive Principle:
Principle #25Self-service

Solution Approach 2:

The calibration function is extracted from the traditional separate calibration process and integrated directly into the image capture and processing workflow. The system separates the calibration reference (the sample container itself) from external calibration standards, allowing calibration to occur automatically during normal operation without requiring separate calibration steps.

Inventive Principle:
Principle #2Taking out (Extraction)

2Measurement precision

If traditional calibration methods with external reference data are used, then measurement accuracy is maintained, but processing time increases due to prior calibration requirements

Engineering Contradiction:
Improvegeometrical property determination accuracyVSAvoidcalibration time
Core Design Contradiction:
Measurement precisionVSLoss of time

Solution Approach 1:

The system performs calibration actions preliminarily by capturing images that contain both the sample container and calibration information simultaneously. The calibration data is extracted and processed in advance during the normal imaging operation, so that when measurement is needed, the calibration is already complete and integrated into the system.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The calibration process and measurement process are merged into a single integrated operation. The same image capture device and processing system used for measurement also perform calibration automatically, combining what were previously separate time-consuming steps into one simultaneous operation.

Inventive Principle:
Principle #5Merging (Combining)

3Reliability

If multiple separate calibration procedures are performed for geometry and color, then comprehensive calibration is achieved, but cost and operational complexity increase

Engineering Contradiction:
Improvecalibration reliabilityVSAvoidcalibration operation simplicity
Core Design Contradiction:
ReliabilityVSEase of operation

Solution Approach 1:

The image processing device performs multiple calibration functions simultaneously using a single integrated process. It extracts both geometrical properties (dimensions, shape, position) and color characteristics (hue, saturation, brightness) from the same image data, eliminating the need for separate geometry calibration and color calibration procedures.

Inventive Principle:
Principle #6Universality (Multi-functionality)

Solution Approach 2:

Geometry calibration and color calibration are merged into a single unified calibration process. The system captures one image containing the sample container and automatically performs both geometrical analysis and color analysis together, reducing the number of operational steps while maintaining comprehensive calibration reliability.

Inventive Principle:
Principle #5Merging (Combining)

Data Source

PatentEP3357842B1Laboratory automation system
Publication Date: 2022.03.23 ROCHE DIAGNOSTICS GMBH
  • EP3357842B1 patent drawingFigure 1
  • EP3357842B1 patent drawingFigure 2~4

AI summary

Laboratory automation system (100) for processing sample containers (145) containing laboratory samples (146) and/or for processing the samples (146), comprising: - a digital camera (160) being adapted to take an image of the sample container (145) together with a calibration element (170), wherein the image comprises image data related to the sample container (145) and image data related to the calibration element (170), and - an image processing device (155) being adapted to determine geometrical properties of the sample container (145) depending on the image data related to the sample container (145) and the image data related to the calibration element (170).