Lab-on-Chip Resonator for Rapid Virus Identification
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Solution Overview
Problem
Existing virus detection methods are time-consuming, costly, and require extensive sample preparation, limiting their ability to quickly identify and quantify viruses accurately.
Innovation Solution
A method using a lab-on-chip based resonator with nanotubes to detect viruses by analyzing radio frequency responses, including amplitude and phase changes at specific temperatures, allowing for the identification of virus types without the need for labeling or biomarkers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional virus detection methods are used, then accurate virus identification can be achieved, but the detection process is time-consuming and requires extensive sample preparation
Solution Approach 1:
The invention extracts only the essential detection function from complex conventional methods by using a resonator that directly detects virus particles in crude samples without requiring viral isolation, extraction, or purification steps. The resonator measures the mass of virus particles directly, eliminating time-consuming preparatory procedures while maintaining detection accuracy.
Solution Approach 2:
The invention replaces complex mechanical and chemical processing systems with a physical measurement system based on resonant frequency detection. Instead of using mechanical separation or chemical assays, the resonator detects virus mass through changes in its resonant frequency, dramatically reducing detection time while preserving identification accuracy.
2Measurement precision
If conventional virus screening techniques are used, then virus quantification can be performed, but the processes are costly and time-consuming
Solution Approach 1:
The resonator system performs self-calibration and automatic measurement, eliminating the need for expensive reagents, specialized equipment, and extensive operator training. The device uses its own resonant properties to detect and quantify viruses, making the process both cost-effective and highly efficient without sacrificing quantification accuracy.
3Measurement precision
If extensive sample preparation is performed, then detection accuracy can be improved, but the complexity of the procedure increases
Solution Approach 1:
The invention extracts only the critical detection function from complex sample preparation protocols. By using a highly sensitive resonator that can detect virus mass directly in crude samples, the method eliminates the need for multiple purification and concentration steps, significantly reducing procedural complexity while maintaining detection accuracy through direct physical measurement.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables rapid, cost-effective, and sensitive virus detection and identification, capable of distinguishing between different virus types, with results obtained in under a minute and suitable for emergency cases.
Implementation Method 1
obtaining a radio frequency response of a lab-on-chip based resonator with virus deposited within a recess of the resonator, determining at least one parameter of the radio frequency response
Data Source
AI summary
Embodiments of the present invention relate to a method comprising obtaining a radio frequency response of a lab-on-chip based resonator with virus deposited within a recess of the resonator, determining at least one parameter of the radio frequency response and identifying a type of the virus or a group to which the virus belongs based on the at least one parameter.