Lachnospiraceae and Ruminococcus Strains for Memory Decline
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Solution Overview
Problem
Current treatments for memory deficits associated with aging and Alzheimer's disease are inadequate, and there is a need for effective methods to ameliorate cognitive decline and improve quality of life in affected individuals.
Innovation Solution
The use of specific Lachnospiraceae spp and Ruminococcus lactaris strains, deposited under CNCM I-5830 and CNCM I-5831, in compositions that can be administered to restore memory abilities and prevent memory deficits by targeting the hippocampal activity in individuals with age-related or Alzheimer's disease-related memory impairments.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used for memory deficits associated with aging and Alzheimer's disease, then current standard care is provided, but effective amelioration of cognitive decline is not achieved
Solution Approach 1:
The patent changes the parameter of treatment approach by transitioning from conventional pharmaceutical treatments to probiotic bacterial strains (Lachnospiraceae spp. and Ruminococcus lactaris) that modify gut microbiota composition, thereby improving cognitive function through gut-brain axis mechanisms
Solution Approach 2:
The patent introduces gut microbiota as an intermediary system between diet/lifestyle and brain function, using probiotic bacteria as mediators to restore hippocampal activity and improve memory deficits through metabolic and inflammatory pathways
2Reliability
If no effective treatment is used, then current inadequate treatment is avoided, but quality of life remains compromised
Solution Approach 1:
The patent employs self-service mechanisms where the probiotic bacteria utilize the host's existing gut environment and metabolic pathways to produce beneficial effects, avoiding the need for complex external intervention systems while improving quality of life
Data Source
AI summary
Lachnospiraceae spp and Ruminococcus lactaris new strains of bacteria for use solely or in combination, in the treatment and prevention of memory decline in an individual, in particular declines of aging or Alzheimer's disease-related origin. Compositions, in particular, an oral composition, including the Lachnospiraceae spp and Ruminococcus lactaris strains and uses thereof.