Combined Lactate–Ketone Body Esters for Low-Ion Delivery

Solution Overview

Problem

Existing preparations of lactate and ketone bodies, such as beta-hydroxybutyrate, suffer from excessive ion loading and unpleasant taste, limiting their ingestion in both food supplements and medicinal settings.

Innovation Solution

Development of lactate/ketone body esters, including pyruvate-BHB compounds (diPyKe), which upon uptake convert into lactate and BHB, providing dual functions as high-energy metabolic substrates and anti-inflammatory agents, while minimizing harmful ion loads.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If lactate and beta-hydroxybutyrate salts are administered to provide beneficial metabolic effects, then therapeutic benefits are achieved, but harmful ion loads (sodium, calcium, potassium, magnesium) are introduced

Engineering Contradiction:

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent uses ester compounds as intermediaries that convert into lactate and beta-hydroxybutyrate in the body. These esters serve as a mediator between the administered compound and the active metabolites, delivering therapeutic benefits without introducing harmful ion loads from traditional salt formulations.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The invention changes the chemical form of lactate and beta-hydroxybutyrate delivery from ionic salt forms to ester forms. This parameter change in molecular structure eliminates the ion load problem while maintaining the metabolic benefits of the compounds.

Inventive Principle:

Principle #35Parameter changes

2Reliability

If traditional lactate and ketone body preparations are used, then therapeutic effects are achieved, but unpleasant taste limits ingestion

Engineering Contradiction:

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent changes the physical-chemical parameters of the compounds by converting them to ester forms, which have different sensory properties including taste compared to the traditional salt forms. This parameter change improves ease of ingestion while maintaining therapeutic efficacy.

Inventive Principle:

Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The esters effectively increase serum concentrations of lactate and BHB, reduce free fatty acids, and suppress appetite, offering therapeutic benefits for conditions like obesity, diabetes, and metabolic syndrome without the drawbacks of traditional salts.

Implementation Method 1

lactate/ketone body esters, including pyruvate-BHB compounds (diPyKe), which upon uptake convert into lactate and BHB

Methodology Applied

Scientific EffectMetabolic conversion: Hydrolysis

Implementation Method 2

The esters effectively increase serum concentrations of lactate and BHB, reduce free fatty acids

Methodology Applied

Scientific EffectMetabolic regulation:

Implementation Method 3

They have protective properties during stress and act through similar, yet distinct, tissue receptors

Methodology Applied

Scientific EffectReceptor-mediated protection:

Data Source

PatentUS20250304523A1Combined lactate and ketone body esters for medical and nutritional use

Publication Date: 2025.10.02

AI summary

The present invention relates to a Lactate/Ketone body ester for preservation of vital organ function and combat inflammation and cancer growth. In particular, the present invention relates to a Lactate/Ketone body ester with the beneficial properties of Lactate and beta-hydroxybutyrate (BHB) on vital organ function, inflammation and cancer growth but without the harmful sodium loads following administration of both Lactate and beta-hydroxybutyrate.