Skin-Derived Lactic Acid Bacteria for Antioxidant and Whitening
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Solution Overview
Problem
Current cosmetic compositions lack effective antioxidant, anti-inflammatory, and whitening properties, particularly those using lactic acid bacteria as a main ingredient, and do not adequately address oxidative stress, inflammation, and melanin hyperpigmentation issues in the skin.
Innovation Solution
Development of a cosmetic and pharmaceutical composition utilizing skin-derived Lactobacillus plantarum subsp. shebah-202, Lactobacillus fermentum subsp. shebah-101, and Lactobacillus paraplantarum subsp. shebah-401 strains, which inhibit reactive oxygen species, nitric oxide production, tyrosinase activity, and melanin production, while synthesizing collagen, thereby providing antioxidant, anti-inflammatory, and whitening effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional cosmetic compositions are used, then basic skin care functions are provided, but antioxidant, anti-inflammatory, and whitening properties are insufficient
Solution Approach 1:
The patent changes the functional parameters of the cosmetic composition by incorporating specific skin-derived lactic acid bacteria strains (Lactobacillus plantarum subsp. shebah-202, Lactobacillus fermentum subsp. shebah-101, and Lactobacillus paraplantarum subsp. shebah-401) that possess documented antioxidant, anti-inflammatory, and whitening activities. These bacterial strains produce beneficial metabolites including lactic acid, acetic acid, and other compounds that actively counteract oxidative stress, reduce inflammation, and inhibit melanin production, thereby enhancing the functional reliability of the composition without requiring complex multi-ingredient formulations.
2Reliability
If lactic acid bacteria are used as main ingredient, then functional effects are achieved, but the composition becomes burdensome to use continuously
Solution Approach 1:
The patent employs skin-derived lactic acid bacteria that naturally reside on the human skin surface, allowing the composition to work with the skin's own microbiome rather than introducing foreign agents. The bacteria produce self-sustaining beneficial effects through their metabolic activities, including the continuous generation of lactic acid for exfoliation and antioxidant protection, anti-inflammatory compounds for reducing redness and irritation, and melanin-inhibiting substances for whitening. This self-service mechanism enables effective functional results without requiring heavy or cumbersome formulation.
3Object-affected harmful factors
If oxidative stress is increased, then skin aging and damage occur, but natural antioxidants become incapacitated
Solution Approach 1:
The patent introduces skin-derived lactic acid bacteria as intermediary agents that mediate between oxidative stress and the skin's natural antioxidant defense system. The bacteria produce and secrete various antioxidant compounds including superoxide dismutase, catalase, and vitamin E analogs, which actively scavenge reactive oxygen species and neutralize free radicals. These bacterial-derived antioxidants serve as a bridge, enhancing the skin's natural antioxidant capacity without overwhelming or interfering with existing endogenous antioxidant enzymes, thereby maintaining system effectiveness even under high oxidative stress conditions.
4Object-affected harmful factors
If melanin production is increased, then UV protection is enhanced, but hyperpigmentation and spots occur
Solution Approach 1:
The patent applies local quality control by using skin-derived lactic acid bacteria that selectively inhibit melanin production in hyperpigmented areas while preserving normal melanin function for UV protection. The bacteria produce specific compounds such as lactic acid, acetic acid, and other metabolites that locally inhibit tyrosinase activity and disrupt melanin synthesis pathways in melanocytes. This localized inhibition occurs without affecting overall melanin production necessary for UV shielding, as the bacterial action is concentrated in areas with excessive melanin deposition. The composition thereby addresses hyperpigmentation and spots while maintaining adequate UV protection through natural melanin in non-hyperpigmented skin regions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The novel lactic acid bacteria strains effectively inhibit oxidative stress, inflammation, and melanin production, offering safe and side-effect-free solutions for skin health issues such as wrinkles, acne, and hyperpigmentation, and can be used in both cosmetic and food products.
Implementation Method 1
lactic acid bacteria are bacteria that play a beneficial role in the human body and produce lactic acid using sugars such as carbohydrates
Implementation Method 2
The identified lactic acid bacteria have abilities to inhibit the production of reactive oxygen species... exhibit antioxidant activity
Implementation Method 3
inhibit tyrosinase activity, inhibit melanin production... exhibit whitening activity
Data Source
AI summary
The present invention relates to an antioxidant, anti-inflammatory and whitening composition containing skin-derived lactic acid bacteria. In particular, the present invention relates to: an antioxidant, anti-inflammatory or whitening functional cosmetic composition, a food composition, a pharmaceutical composition for preventing or treating inflammation-related skin disease, and a pharmaceutical composition for preventing or treating melanin hyperpigmentation disease, which contain, as an active ingredient, a Lactobacillus plantarum subsp. shebah-202 (accession number: KCTC14087BP) strain, a Lactobacillus fermentum subsp. shebah-101 (accession number: KCTC14086BP) strain or a Lactobacillus paraplantarum subsp. shebah-401 (accession number: KCTC14088BP) strain, which is a novel lactic acid bacteria strain isolated and identified from human skin, a culture thereof, a lysate thereof, or an extract thereof.