Lactic Acid Bacteria and Fatty Acid Feed for IL-12 Immunostimulation

Solution Overview

Problem

There is no report on the enhanced IL-12 production promoting effect, immunostimulatory effect, and bacteriostatic effect when Lactobacillus plantarum strain L-137 or its processed products are combined with fatty acids or their salts, and their use in feeds has not been explored.

Innovation Solution

The combination of Lactobacillus plantarum strain L-137 or its processed products with fatty acids or their salts exhibits enhanced IL-12 production, immunostimulation, and bacteriostasis, making them suitable for feeds and compositions.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If Lactobacillus plantarum strain L-137 or its processed products are combined with fatty acids or their salts, then the IL-12 production promoting effect and immunostimulatory effect are enhanced, but the device complexity and formulation complexity increase

Engineering Contradiction:

Improveimmunostimulatory effectVSAvoidformulation complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent combines Lactobacillus plantarum strain L-137 (or its processed products) with fatty acids or their salts to create a composite feed composition. This merging of two distinct components (probiotic bacteria and fatty acids) produces a synergistic effect that enhances IL-12 production and immunostimulatory activity beyond what either component achieves alone, while maintaining a relatively simple two-component formulation structure.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite material system by formulating Lactobacillus plantarum strain L-137 with specific fatty acids (such as caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, or alpha-linolenic acid) or their salts. This composite approach leverages the immunomodulatory properties of the probiotic combined with the metabolic effects of fatty acids to achieve enhanced therapeutic outcomes.

Inventive Principle:

Principle #40Composite materials

2Object-affected harmful factors

If Lactobacillus plantarum strain L-137 or its processed products are combined with fatty acids or their salts, then the bacteriostatic effect is achieved, but the device complexity and formulation complexity increase

Engineering Contradiction:

Improvebacterial growth inhibitionVSAvoidformulation complexity

Core Design Contradiction:

Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

The patent combines Lactobacillus plantarum strain L-137 (or its processed products) with fatty acids or their salts to create a composite feed composition. This merging of two distinct components (probiotic bacteria and fatty acids) produces a synergistic effect that enhances IL-12 production and immunostimulatory activity beyond what either component achieves alone, while maintaining a relatively simple two-component formulation structure.

Inventive Principle:

Principle #5Merging (Combining)

Solution Approach 2:

The invention creates a composite material system by formulating Lactobacillus plantarum strain L-137 with specific fatty acids (such as caprylic acid, capric acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, or alpha-linolenic acid) or their salts. This composite approach leverages the immunomodulatory properties of the probiotic combined with the metabolic effects of fatty acids to achieve enhanced therapeutic outcomes.

Inventive Principle:

Principle #40Composite materials

3Reliability

If the amount of Lactobacillus plantarum strain L-137 or its processed products in the feed is increased to enhance immunostimulation, then the immunostimulatory effect is improved, but the loss of substance and cost increase

Engineering Contradiction:

Improveimmunostimulatory effectVSAvoidmaterial cost

Core Design Contradiction:

ReliabilityVSLoss of substance

Solution Approach 1:

The patent optimizes the concentration parameters of both Lactobacillus plantarum strain L-137 and fatty acids in the feed formulation to achieve the desired immunostimulatory effect at minimal effective doses. By carefully controlling the amounts of each component, the formulation maximizes therapeutic benefit while minimizing material consumption and cost.

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent combines Lactobacillus plantarum strain L-137 (or its processed products) with fatty acids or their salts to create a composite feed composition. This merging of two distinct components (probiotic bacteria and fatty acids) produces a synergistic effect that enhances IL-12 production and immunostimulatory activity beyond what either component achieves alone, allowing for reduced dosing of individual components while maintaining or enhancing overall efficacy.

Inventive Principle:

Principle #5Merging (Combining)

Data Source

PatentUS12599638B2Feed and composition comprising lactic acid bacteria and fatty acid

Publication Date: 2026.04.14 HOUSE WELLNESS FOODS

AI summary

A problem to be solved by the present invention is to provide one or more selected from (1) a feed comprising Lactobacillus plantarum strain L-137 or a processed product thereof and a fatty acid or a salt thereof, (2) a composition for enhancing IL-12 production, comprising Lactobacillus plantarum strain L-137 or a processed product thereof and a fatty acid or a salt thereof, (3) a composition for immunostimulation, comprising Lactobacillus plantarum strain L-137 or a processed product thereof and a fatty acid or a salt thereof, and (4) a composition for bacteriostasis, comprising Lactobacillus plantarum strain L-137 or a processed product thereof and a fatty acid or a salt thereof. The problem is solved by providing one or more of the feed or the compositions.