Lactide Purification via Meso-Lactide Recycling

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Solution Overview

Problem

Current methods for producing polylactide suffer from yield losses and inefficiencies due to the difficulty in separating and purifying lactide streams, particularly in removing meso-lactide, which results in impurities and reduced polymerization rates, leading to increased costs and lower-quality polylactide products.

Innovation Solution

A process involving the formation of low molecular weight poly(lactic acid), depolymerization to crude lactide, separation of meso-lactide to enrich the S,S- and R,R-lactide streams, and recycling of the meso-lactide stream to adjust the mole fractions of lactide forms, thereby reducing impurities and enhancing polymerization efficiency.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Stability of the object's composition

If meso-lactide is removed from the lactide stream to produce highly crystalline polylactide, then the crystallinity and thermal properties of the product are improved, but the yield is reduced due to the removal of this valuable component

Engineering Contradiction:
ImprovecrystallinityVSAvoidyield
Core Design Contradiction:
Stability of the object's compositionVSLoss of substance

Solution Approach 1:

The patent applies the principle of discarding and recovering by separating meso-lactide from the lactide stream and then recycling it back to the depolymerization step. This allows the meso-lactide to be recovered and reused, converting what would have been a discarded byproduct into a valuable resource that contributes to non-crystalline regions in the final polylactide product, thereby improving overall yield while maintaining desired crystallinity levels.

Inventive Principle:
Principle #34Discarding and recovering

2Manufacturing precision

If multiple purification steps are implemented to remove impurities from the lactide stream, then the purity of the lactide is improved, but the process complexity and operational costs increase

Engineering Contradiction:
ImprovepurityVSAvoidprocess complexity
Core Design Contradiction:
Manufacturing precisionVSDevice complexity

Solution Approach 1:

The patent applies the principle of extraction by specifically targeting and removing meso-lactide from the lactide stream through a dedicated separation step. This focused extraction approach allows for effective purification by removing the specific component that interferes with polymerization, while avoiding the need for multiple complex purification steps that would be required to remove all possible impurities, thus balancing purity requirements with process simplicity.

Inventive Principle:
Principle #2Taking out (Extraction)

3Productivity

If meso-lactide is present in the lactide stream, then the polymerization rate is reduced due to impurities, but the yield is improved by retaining this component for recycling

Engineering Contradiction:
Improvepolymerization rateVSAvoidyield
Core Design Contradiction:
ProductivityVSLoss of substance

Solution Approach 1:

The patent applies the principle of continuity of useful action by implementing a continuous recycling loop where meso-lactide is separated, recycled back to the depolymerization step, and continuously converted into useful products. This continuous process ensures that the meso-lactide component is not simply discarded but is continuously utilized, maintaining high overall yield while the separation step ensures that the polymerization process is not inhibited by excessive meso-lactide presence.

Inventive Principle:
Principle #20Continuity of useful action

4Productivity

If the lactide stream is highly purified to remove all impurities, then the polymerization efficiency is improved, but the operational costs and time for additional purification steps increase

Engineering Contradiction:
Improvepolymerization efficiencyVSAvoidpurification time
Core Design Contradiction:
ProductivityVSLoss of time

Solution Approach 1:

The patent applies the principle of partial action by implementing a selective purification approach that removes only the specific impurity (meso-lactide) that significantly affects polymerization efficiency, rather than attempting to remove all possible impurities. This partial purification is sufficient to achieve the desired polymerization efficiency while minimizing the time and resources required for the purification process, avoiding excessive action that would not provide additional benefits.

Inventive Principle:
Principle #16Partial or excessive action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This process results in a cleaner, more purified lactide stream with improved polymerization rates and reduced operational costs, allowing for the production of polylactide with desired crystalline properties while minimizing the need for additional purification steps.

Implementation Method 1

depolymerizing the low molecular weight poly(lactic acid)

Methodology Applied
Scientific EffectDepolymerization: Pyrolysis

Implementation Method 2

at least a portion of the meso-lactide in the recycled meso-lactide stream is converted to a mixture of S,S-, meso- and R,R-lactide

Methodology Applied
Scientific EffectRacemization:

Data Source

PatentEP2406246B1Methods for producing lactide with recycle of meso-lactide
Publication Date: 2018.08.15 NATUREWORKS LLC
  • EP2406246B1 patent drawingFigure 1
  • EP2406246B1 patent drawing
  • EP2406246B1 patent drawing

AI summary

An S, S- and R,R-lactide stream suitable for polymerization is prepared by producing a low molecular weight poly(lactic acid), depolymerizing the low molecular weight poly(lactic acid) to form a mixture of S, S-, R,R- and meso- lactide, and separating meso-lactide from this mixture to form an S, S- and R,R- lactide stream. Meso-lactide is recycled into the process, and shifts the mole fractions of the lactides in the lactide mixture that is produced.