Lactobacillus Bacillus Microbial Composition for Poultry Pathogen Control

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Solution Overview

Problem

The poultry industry faces challenges in controlling gastrointestinal pathogens like avian pathogenic Escherichia coli (APEC) in day-of-hatch birds, leading to variable gut microbiomes, disrupted intestinal homeostasis, and significant financial losses due to diseases such as colibacillosis, with existing antibiotic treatments being phased out in favor of antibiotic-free alternatives.

Innovation Solution

A direct-fed microbial composition comprising isolated Lactobacillus and Bacillus strains is developed to inhibit pathogenic bacteria, modulate the immune response, and establish a healthy gut microbiome, including strains like Lactobacillus plantarum Lp-115 and Lactobacillus salivarius Ls-33, which are administered to birds at hatch to reduce APEC populations and enhance immunological protection.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If antibiotics are used to control bacterial challenges such as APEC in the hatchery, then bacterial pathogen populations are reduced, but antibiotic residues and resistance issues arise and antibiotic-free market demand cannot be met

Engineering Contradiction:

Improvepathogen control effectivenessVSAvoidantibiotic residues and resistance

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

The patent introduces beneficial microorganisms (Lactobacillus and Bacillus strains) as intermediary agents that mediate the control of pathogenic bacteria through competitive exclusion and immune modulation, replacing direct antibiotic action while achieving pathogen control without antibiotic residues or resistance issues

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent converts the harmful presence of pathogenic bacteria into a beneficial outcome by using the immune challenge they pose to stimulate the development of the bird's immune system, while simultaneously using probiotic microorganisms to modulate this response and achieve protection without antibiotics

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

2Reliability

If beneficial bacteria colonization is established early in the gastrointestinal tract, then intestinal homeostasis and immunological protection are improved, but inconsistent colonization levels lead to variable gut microbiomes and reduced reliability

Engineering Contradiction:

Improveintestinal homeostasis stabilityVSAvoidgut microbiome consistency

Core Design Contradiction:

ReliabilityVSStability of the object's composition

Solution Approach 1:

The patent applies beneficial microorganisms directly to the gastrointestinal tract at the critical early stage of hatch, establishing colonization before pathogenic bacteria can dominate, thereby ensuring consistent and reliable gut microbiome composition and intestinal homeostasis from the beginning of life

Inventive Principle:

Principle #10Preliminary action

Solution Approach 2:

The patent combines multiple strains of Lactobacillus and Bacillus microorganisms into a single composition that works synergistically to establish stable colonization, improve intestinal homeostasis, and ensure consistent gut microbiome composition across different birds

Inventive Principle:

Principle #5Merging (Combining)

3Adaptability or versatility

If pathogenic bacterial populations are allowed to establish, then natural colonization processes occur, but APEC populations can translocate to the bloodstream and cause colibacillosis with high mortality rates

Engineering Contradiction:

Improvenatural colonization processVSAvoidcolibacillosis disease and mortality

Core Design Contradiction:

Adaptability or versatilityVSObject-affected harmful factors

Solution Approach 1:

The patent applies beneficial microorganisms in advance to occupy ecological niches and compete for resources, preventing pathogenic bacteria from establishing significant populations before they can cause harm, thereby blocking the pathway to colibacillosis while allowing natural colonization processes to proceed in a controlled manner

Inventive Principle:

Principle #9Preliminary anti-action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The microbial composition effectively reduces APEC and Clostridium perfringens levels in the gastrointestinal tract, improves bird performance, and decreases mortality and disease incidence without the use of antibiotics, promoting a balanced gut microbiome and immune system development.

Implementation Method 1

provide a competitive environment to exclude or reduce the APEC populations

Methodology Applied

Scientific EffectCompetitive exclusion:

Implementation Method 2

inhibit pathogenic bacterial populations

Methodology Applied

Scientific EffectAntimicrobial production:

Implementation Method 3

modulate an immune response in a bird

Methodology Applied

Scientific EffectImmune modulation:

Data Source

PatentUS11298383B2Lactobacillus and bacillus based direct fed microbial treatment for poultry and method of use

Publication Date: 2022.04.12 CHURCH & DWIGHT CO INC

AI summary

This disclosure relates generally to a microbial treatment for poultry. More particularly, the disclosure relates to a direct fed microbial composition including one or more lactic acid bacteria strains in combination with one or more Bacillus bacteria strains configured to inhibit gastrointestinal pathogens in a bird. A method of use is also disclosed herein.