Lactobacillus sp. BB1 Memory Enhancement via Gut-Brain Axis
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Solution Overview
Problem
Current probiotics are primarily designed to adjust intestinal function and improve nutrition metabolism, but there is a lack of effective solutions for enhancing cognitive competence, particularly for healthy individuals and those with memory impairment due to aging or neurodegenerative diseases.
Innovation Solution
The use of Lactobacillus sp. BB1, deposited with accession number GDMCC No: 61578, in microbial preparations, fermented foods, feed additives, and healthcare products to improve memory ability and alleviate memory impairment by promoting neural signal transmission and glyceryl phosphatide metabolism.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional probiotics are used to adjust intestinal function, then intestinal health is improved, but cognitive competence and memory ability remain unaffected
Solution Approach 1:
The patent applies multi-functionality by selecting Lactobacillus sp. BB1 that simultaneously performs intestinal health improvement and cognitive enhancement. The probiotic strain is designed to work through multiple mechanisms: adjusting intestinal flora composition and directly enhancing memory function via the gut-brain axis, thereby resolving the contradiction between single-function intestinal adjustment and multi-function cognitive improvement
2Quantity of substance
If probiotics are used for nutrition metabolism improvement, then nutritional status is enhanced, but memory impairment treatment effectiveness is insufficient
Solution Approach 1:
The patent uses the gut-brain axis as an intermediary mechanism. Lactobacillus sp. BB1 first improves nutrition metabolism in the intestinal tract, then transmits beneficial effects to the brain through neural, endocrine, and immune pathways of the gut-brain axis. This intermediary approach connects nutritional metabolism improvement with memory impairment treatment, resolving the contradiction between these two functions
3Adaptability or versatility
If existing intelligence reinforcing products are used, then some cognitive support is provided, but effectiveness for learning and memory improvement is very limited
Solution Approach 1:
The patent changes the key parameter from general cognitive support to specific memory enhancement through selective probiotic strain identification. Lactobacillus sp. BB1 was screened and selected based on its unique ability to significantly improve memory performance in behavioral tests. The strain exhibits optimized parameters for memory improvement while maintaining intestinal health benefits, resolving the contradiction between broad cognitive support and effective memory improvement
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Lactobacillus sp. BB1 significantly enhances long-term memory ability, promotes neural receptor expression, and improves glyceryl phosphatide levels in the blood, demonstrating its effectiveness in improving memory in both animal experiments and potential applications in functional foods and healthcare products.
Implementation Method 1
The disclosure provides Lactobacillus sp. BB1 that has been deposited in GDMCC on 25th, Mar., 2021, with an accession number: GDMCC No: 61578... metabolism of glyceryl phosphatide, amino acids and the like in the intestinal tract can be promoted
Implementation Method 2
transmission of neural signals can be promoted... expression of neural receptors in the intestinal tract and the brain can be affected
Data Source
AI summary
The disclosure discloses Lactobacillus sp. BB1 enhancing memory ability, a fermented food and application thereof, and belongs to the technical field of microorganisms. The Lactobacillus sp. BB1 disclosed by the disclosure can be used for preparing functional foods, health-care products and drugs that enhance the memory ability of a healthy individual and improve memory impairment. The disclosure further provides the fermented food. The fermented food is prepared by fermentation with Lactobacillus sp. BB1, comprises a solid food, a liquid food and a semisolid food, and has a wide application prospect.