Three-Strain Lactobacillus Composition for Aging-Related Muscle Loss
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Solution Overview
Problem
Current inventions do not utilize mixed strains of Lactobacillus sp. for the prevention and treatment of aging-related disorders and obesity, despite the importance of intestinal microflora balance in health and the increasing interest in Lactobacillus for anti-aging benefits.
Innovation Solution
A composition comprising Lactobacillus fermentum GB102, Lactobacillus fermentum GB103, and Lactobacillus plantarum GB104 strains, or their lysates and culture solutions, is used as an active ingredient to address aging-related disorders and obesity, with potential anti-aging and antioxidant effects.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If single strain of Lactobacillus is used as active ingredient, then the composition is simple to manufacture, but the effectiveness for preventing and treating aging-related disorders is limited
Solution Approach 1:
The patent combines three different Lactobacillus strains (Lactobacillus plantarum KCTC 14107BP, Lactobacillus fermentum KCTC 14105BP, and Lactobacillus fermentum KCTC 14106BP) into a single composition. This merging of multiple strains synergistically enhances the effectiveness for preventing and treating aging-related disorders such as sarcopenia, while the composition remains manufacturable through standardized fermentation processes.
2Reliability
If mixed strains of Lactobacillus sp. are used, then the anti-aging and antioxidant effects are enhanced, but the manufacturing process becomes more complex
Solution Approach 1:
The patent specifies precise parameters for manufacturing the mixed strain composition, including incubation conditions (37°C, anaerobic environment), culture medium composition (MRS medium with specific pH range of 5.5-6.5), and strain ratios. These parameter specifications standardize the manufacturing process, making it easier to produce consistent high-quality mixed strain compositions with enhanced anti-aging and antioxidant effects.
3Reliability
If higher concentration of Lactobacillus strains is used, then the therapeutic effect is improved, but the cost of production increases
Solution Approach 1:
The patent employs a multi-strain approach where three Lactobacillus strains work synergistically at optimized concentrations. This partial action principle allows achieving enhanced therapeutic effects through the combined action of multiple strains at moderate concentrations, rather than requiring excessively high concentrations of a single strain, thereby reducing production costs while maintaining or improving therapeutic efficacy.
Data Source
AI summary
Provided are a mixture of three species of Lactobacillus fermentum strain and Lactobacillus plantarum strain and use thereof. A composition according to one aspect including, as an active ingredient, a mixture of Lactobacillus fermentum strains GB102 and GB103 and Lactobacillus plantarum strain GB104; or a lysate or culture solution thereof, or an extract of the culture solution, can be usefully used for the prevention or treatment of muscle-related disorders or obesity by alleviating the decrease in grip strength induced by aging or reducing the change in intestinal microbial environment induced by aging.