Lactobacillus plantarum MG4229 for blood glucose control
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Solution Overview
Problem
Current treatments for diabetes mellitus, particularly type 2, face challenges with side effects and resistance to drugs, and there is a need for natural products with antioxidant properties to address hyperlipidemia, diabetes, and aging-related issues.
Innovation Solution
A Lactobacillus plantarum MG4229 strain with high blood glucose lowering activity and antioxidant properties, exhibiting excellent α-glucosidase inhibitory, α-amylase inhibitory, and insulin resistance improvement effects, is identified and developed for use in compositions to manage diabetes and provide antioxidant benefits.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If drug therapy is used to control blood glucose level, then blood glucose control is achieved, but side effects and patient chemical resistance occur
Solution Approach 1:
The patent uses probiotic bacteria (Lactobacillus plantarum MG4229) as a biological agent that can be safely administered without causing harmful side effects or chemical resistance, replacing conventional drugs that have these adverse effects
Solution Approach 2:
The probiotic strain acts as an intermediary substance that modulates the body's metabolic processes and immune response to achieve blood glucose control without direct pharmacological intervention, thereby avoiding drug-related side effects and resistance
2Reliability
If conventional diabetes treatment is used, then blood glucose level is controlled, but quality of life is reduced due to side effects
Solution Approach 1:
The probiotic strain serves as a safe, non-harmful biological agent that improves blood glucose control without the quality-of-life reducing side effects associated with conventional diabetes medications
Solution Approach 2:
The probiotic strain utilizes the body's own immune system and metabolic processes to achieve blood glucose control, rather than imposing external pharmacological agents that interfere with normal physiological functions and reduce quality of life
3Object-affected harmful factors
If natural products with antioxidant properties are used, then antioxidant effects are achieved, but effectiveness in managing diabetes is insufficient
Solution Approach 1:
The probiotic strain Lactobacillus plantarum MG4229 performs multiple functions simultaneously: it provides antioxidant effects, lowers blood glucose levels, improves insulin sensitivity, and modulates immune response, making it a comprehensive diabetes management solution rather than a single-function supplement
Solution Approach 2:
The probiotic strain acts as a composite biological agent that combines multiple active components (bacterial cells, metabolites, and modulatory proteins) to achieve synergistic effects in antioxidant activity and diabetes management, surpassing the effectiveness of single-component natural products
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The Lactobacillus plantarum MG4229 strain effectively lowers blood glucose levels, improves insulin resistance, and exhibits strong antioxidant activity, making it suitable for preventing or treating diabetes mellitus and promoting overall health, with potential applications in health functional foods and pharmaceutical compositions.
Implementation Method 1
exhibiting excellent α-glucosidase inhibitory, α-amylase inhibitory, and insulin resistance improvement effects
Implementation Method 2
Lactobacillus plantarum MG4229 strain with high blood glucose lowering activity and antioxidant properties
Data Source
AI summary
Disclosed is a Lactobacillus strain having a blood glucose lowering effect and an antioxidant effect, a culture medium of the strain, and a cell-free supernatant of the strain. Further, a composition for lowering a blood glucose level contains the same. A composition having an antioxidant ability contains the same. The Lactobacillus plantarum MG4229 strain according to the present disclosure has excellent blood glucose lowering activity and antioxidant activity, and has excellent acid tolerance, bile tolerance, auto-aggregation, and adhesion to epithelial cells, and thus is suitable for probiotics, and thus may be used in various ways as a composition for preventing or treating diabetes mellitus or a composition having antioxidant ability.