Lactobacillus Probiotic Composition to Block Skin Pathogen Adhesion
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Solution Overview
Problem
Conventional treatments for skin disorders and UV damage, such as acne and skin aging, often rely on antibiotics that can disrupt the skin microbiota and pose risks, while probiotics have shown potential to restore balance and mitigate skin pathogens.
Innovation Solution
A composition comprising probiotics from the genus Lactobacillus, particularly Lactobacillus paracasei strains DG and LPC-S01, is used to prevent and treat skin disorders by reducing pathogen adhesion, promoting healing, and modulating cytokine expression, while also protecting against UV damage.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If antibiotics are used to treat skin disorders and kill pathogens, then pathogen elimination is effective, but beneficial bacteria are eliminated and adverse events occur
Solution Approach 1:
The patent introduces probiotic bacteria as an intermediary that mediates between pathogen elimination and beneficial bacteria preservation. The probiotics compete with pathogens for adhesion sites and resources, indirectly eliminating pathogens while simultaneously maintaining or restoring beneficial bacterial populations, thus avoiding the harmful effects of direct antibiotic action
Solution Approach 2:
The patent converts the concept of bacterial competition, normally associated with pathogenicity, into a beneficial mechanism. By introducing specific probiotic strains that naturally compete with pathogens through adhesion inhibition and resource competition, the harmful competitive interactions in the microbiome are redirected to favor pathogen suppression while preserving beneficial bacteria
2Stability of the object's composition
If probiotics are used to restore skin microbiota balance, then beneficial bacteria are promoted and pathogen adhesion is reduced, but treatment effectiveness compared to antibiotics may be questioned
Solution Approach 1:
The patent applies preliminary action by pre-treating the skin with probiotics before pathogen establishment or in conjunction with antibiotic therapy. The probiotics establish themselves on skin surfaces first, occupying adhesion sites and creating a protective barrier that prevents pathogen colonization, thereby enhancing overall treatment effectiveness
Solution Approach 2:
The patent changes the parameter of microbial composition in the skin microbiota by introducing specific probiotic strains with defined adhesion properties. This parameter change restores the ecological balance of the microbiome, creating conditions unfavorable for pathogens while maintaining beneficial bacterial populations, thereby ensuring reliable and sustained treatment effectiveness
Data Source
Figure 1A~1C
Figure 2
AI summary
The present invention relates to a composition comprising probiotics, preferably based on bacteria, in particular of the genus Lactobacillus, to be used for the purpose of preventing and/or treating the disorders affecting the skin, in particular inflammatory disorders, in particular autoinflammatory disorders of dermatological interest such as atopic dermatitis. Furthermore, the composition of the invention is useful for preventing and/or reducing the damage induced by UV radiation, in particular skin aging.