Lactobacillus plantarum PS128 Modulates Neurotransmitters
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Solution Overview
Problem
Current treatments for stress-induced disorders such as anxiety, depression, and irritable bowel syndrome are inadequate, as they do not effectively address the underlying gut-brain axis alterations and neurotransmitter imbalances caused by stress.
Innovation Solution
The use of Lactobacillus plantarum subsp. plantarum PS128, administered orally, which alters gut microbiota and neurotransmitter levels, reducing serum corticosterone and increasing dopamine, dihydroxyphenylacetic acid, and homo-vanillic acid levels, thereby treating or preventing stress-induced disorders.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional psychiatric medicines are used to treat stress-induced disorders, then some symptoms may be alleviated, but they do not effectively address the underlying gut-brain axis alterations and neurotransmitter imbalances
Solution Approach 1:
The patent uses Lactobacillus plantarum subsp. plantarum PS128 as an intermediary organism to mediate the gut-brain axis communication. The probiotic strain acts as a biological mediator that modulates neurotransmitter levels and HPA axis function, thereby treating stress-induced disorders through the gut microbiota pathway rather than direct central nervous system intervention
Solution Approach 2:
The probiotic Lactobacillus plantarum subsp. plantarum PS128 enables the host's own gut microbiota and neuroendocrine systems to self-regulate stress responses. The bacterium restores the body's natural ability to maintain neurotransmitter balance and regulate the HPA axis, allowing the physiological systems to serve themselves without continuous external pharmaceutical intervention
2Reliability
If Lactobacillus plantarum subsp. plantarum PS128 is administered to treat stress-induced disorders, then neurotransmitter levels are improved and behavioral deficits are reduced, but the mechanism involves complex interactions with gut microbiota and HPA axis
Solution Approach 1:
Lactobacillus plantarum subsp. plantarum PS128 serves as a biological intermediary that bridges gut microbiota modulation and central nervous system effects. The probiotic strain mediates communication between the gut and brain through vagus nerve stimulation and neurotransmitter modulation, simplifying the complex gut-brain axis interactions into a single actionable therapeutic agent
Solution Approach 2:
The patent utilizes specific parameter changes in the probiotic strain's metabolic activity to achieve therapeutic effects. By monitoring and controlling parameters such as neurotransmitter production levels, HPA axis activation states, and behavioral outcome measures, the complex biological mechanism is reduced to quantifiable therapeutic parameters that can be optimized and standardized
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Lactobacillus plantarum subsp. plantarum PS128 significantly decreases serum corticosterone levels and increases neurotransmitter levels, improving behavioral deficits and stress responses in mice, effectively treating or preventing anxiety, depression, and irritable bowel syndrome.
Implementation Method 1
a medium comprising one or more carbohydrate substrates tested to be able to support (e.g., '+') fermentation of Lactobacillus plantarum subsp. plantarum PS128
Data Source
AI summary
The present invention provides an isolated lactic acid bacterium, Lactobacillus plantarum subsp. plantarum PS128 deposited under DSMZ Accession No. DSM 28632, for prophylaxis or treatment of a stress-induced disorder. The present invention further provides a composition for prophylaxis or treatment of a stress-induced disorder that comprises Lactobacillus plantarum subsp. plantarum PS128. Moreover, the present invention provides a method for prophylaxis or treatment of a stress-induced disorder in a subject that comprises a step of administering an effective amount of Lactobacillus plantarum subsp. plantarum PS128 to the subject.