Lactobacillus rhamnosus MP108 for Calcium Absorption

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Solution Overview

Problem

Current calcium supplements often fail to enhance calcium absorption effectively, leading to potential calcium deficiency-associated disorders, and may even increase the risk of forming calcium-containing kidney stones.

Innovation Solution

Administering a composition containing a culture of Lactobacillus rhamnosus MP108, which is deposited under the Budapest Treaty, to increase calcium absorption in subjects with calcium deficiency-associated disorders.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Quantity of substance

If calcium supplements are used to increase calcium intake, then calcium deficiency-associated disorders are alleviated, but calcium absorption by the intestine is not effective and urinary calcium level increases leading to kidney stone formation

Engineering Contradiction:

Improvecalcium intakeVSAvoidcalcium absorption efficiency

Core Design Contradiction:

Quantity of substanceVSReliability

Solution Approach 1:

The patent uses Lactobacillus rhamnosus MP108 as an intermediary substance between calcium supplements and the intestinal absorption system. This probiotic strain mediates the absorption process by enhancing intestinal calcium transport mechanisms, thereby improving the reliability of calcium absorption while maintaining safe urinary calcium levels

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent changes the biological state of the intestinal system by introducing Lactobacillus rhamnosus MP108, which modifies the intestinal environment and transport parameters. This enables more effective calcium absorption through enhanced TRPV6 channel expression and improved intestinal calcium transport capacity

Inventive Principle:

Principle #35Parameter changes

2Quantity of substance

If excessive calcium supplements are used, then calcium deficiency is prevented, but urinary calcium level increases resulting in formation of calcium-containing kidney stones

Engineering Contradiction:

Improvecalcium intakeVSAvoidkidney stone formation risk

Core Design Contradiction:

Quantity of substanceVSObject-affected harmful factors

Solution Approach 1:

Lactobacillus rhamnosus MP108 acts as a mediator that improves calcium absorption efficiency in the intestine, ensuring that more calcium is absorbed before reaching the urinary system. This reduces the harmful effect of excessive urinary calcium that leads to kidney stone formation

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent replaces the passive mechanical absorption process with an active biological enhancement system. The probiotic Lactobacillus rhamnosus MP108 actively enhances calcium transport mechanisms, providing more efficient calcium uptake that prevents calcium overload in the urinary system

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The use of Lactobacillus rhamnosus MP108 significantly enhances intestinal calcium ion transport and expression of the TRPV6 calcium channel protein, effectively improving calcium absorption and alleviating calcium deficiency-associated disorders.

Implementation Method 1

The culture of the Lactobacillus rhamnosus MP108 significantly enhances intestinal calcium ion transport

Methodology Applied

Scientific EffectBiological transport:

Implementation Method 2

expression of the TRPV6 calcium channel protein

Methodology Applied

Scientific EffectProtein expression:

Data Source

PatentUS20250073289A1Method for increasing calcium absorption using culture of lactobacillus rhamnosus MP108

Publication Date: 2025.03.06 GLACT BIOTECH

AI summary

A method for increasing calcium absorption includes administering to a subject in need thereof a composition containing a culture of Lactobacillus rhamnosus MP108. The Lactobacillus rhamnosus MP108 is deposited under the terms of the Budapest Treaty at the China General Microbiological Culture Collection Center (CGMCC) under an accession number CGMCC 21225.